{"doi":"10.1016/j.celrep.2023.112239","title":"HSC-independent definitive hematopoiesis persists into adult life","abstract":"It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprisingly, we find that significant percentages of lymphocytes are not derived from HSCs, even in 1-year-old mice. Instead, multiple waves of hematopoiesis occur from embryonic day 7.5 (E7.5) to E11.5 endothelial cells, which simultaneously produce HSCs and lymphoid progenitors that constitute many layers of adaptive T and B lymphocytes in adult mice. Additionally, HSC lineage tracing reveals that the contribution of fetal liver HSCs to peritoneal B-1a cells is minimal and that the majority of B-1a cells are HSC independent. Our discovery of extensive HSC-independent lymphocytes in adult mice attests to the complex blood developmental dynamics spanning the embryo-to-adult transition and challenges the paradigm of HSCs exclusively underpinning the postnatal immune system.","journal":"Cell Reports","year":2023,"id":319326,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274981,"name":"Haichao Wei","orcid":"0000-0001-5447-5202","position":1,"is_corresponding":false},{"id":818353,"name":"Takashi Yamanashi","orcid":"0000-0003-2362-2067","position":2,"is_corresponding":false},{"id":818354,"name":"Nathália Azevedo Portilho","orcid":"0000-0003-2578-7340","position":3,"is_corresponding":false},{"id":818840,"name":"Samuel Cornelius","orcid":null,"position":4,"is_corresponding":false},{"id":818841,"name":"Noemi Valiente","orcid":null,"position":5,"is_corresponding":false},{"id":818842,"name":"Chika Nishida","orcid":null,"position":6,"is_corresponding":false},{"id":278879,"name":"Haizi Cheng","orcid":"0000-0003-1525-0099","position":7,"is_corresponding":false},{"id":915916,"name":"Augusto Latorre","orcid":null,"position":8,"is_corresponding":false},{"id":12549,"name":"Wenjin Zheng","orcid":null,"position":9,"is_corresponding":false},{"id":61582,"name":"Joonsoo Kang","orcid":"0000-0001-8419-7995","position":10,"is_corresponding":false},{"id":105295,"name":"Jun Seita","orcid":"0000-0002-3008-3615","position":11,"is_corresponding":false},{"id":281761,"name":"David Shih","orcid":"0000-0002-9802-4937","position":12,"is_corresponding":false},{"id":631234,"name":"Jia Qian Wu","orcid":null,"position":13,"is_corresponding":false},{"id":641028,"name":"Momoko Yoshimoto","orcid":"0000-0002-7272-6682","position":14,"is_corresponding":false},{"id":818352,"name":"Michihiro Kobayashi","orcid":"0000-0001-6065-6026","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:07:12.004111Z","pmid":"36906851","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}