{"doi":"10.1016/j.celrep.2023.112195","title":"TRIB2 safeguards naive T cell homeostasis during aging","abstract":"Naive CD4 + T cells are more resistant to age-related loss than naive CD8 + T cells, suggesting mechanisms that preferentially protect naive CD4 + T cells during aging. Here, we show that TRIB2 is more abundant in naive CD4 + than CD8 + T cells and counteracts quiescence exit by suppressing AKT activation. TRIB2 deficiency increases AKT activity and accelerates proliferation and differentiation in response to interleukin-7 (IL-7) in humans and during lymphopenia in mice. TRIB2 transcription is controlled by the lineage-determining transcription factors ThPOK and RUNX3. Ablation of Zbtb7b (encoding ThPOK) and Cbfb (obligatory RUNT cofactor) attenuates the difference in lymphopenia-induced proliferation between naive CD4 + and CD8 + cells. In older adults, ThPOK and TRIB2 expression wanes in naive CD4 + T cells, causing loss of naivety. These findings assign TRIB2 a key role in regulating T cell homeostasis and provide a model to explain the lesser resilience of CD8 + T cells to undergo changes with age.","journal":"Cell Reports","year":2023,"id":325698,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384812,"name":"Ines Sturmlechner","orcid":"0000-0003-1272-5618","position":1,"is_corresponding":false},{"id":666722,"name":"Huimin Zhang","orcid":"0000-0003-0895-5920","position":2,"is_corresponding":false},{"id":293961,"name":"Jun Jin","orcid":"0000-0002-5018-144X","position":3,"is_corresponding":false},{"id":285053,"name":"Bin Hu","orcid":"0000-0003-0836-0935","position":4,"is_corresponding":false},{"id":285054,"name":"Rohit R. Jadhav","orcid":"0000-0002-2999-6329","position":5,"is_corresponding":false},{"id":475689,"name":"Fengqin Fang","orcid":"0000-0003-3262-8743","position":6,"is_corresponding":false},{"id":235212,"name":"Cornelia M. Weyand","orcid":"0000-0003-2230-9802","position":7,"is_corresponding":false},{"id":235213,"name":"Jörg J. Goronzy","orcid":"0000-0001-7670-1856","position":8,"is_corresponding":false},{"id":326223,"name":"Wenqiang Cao","orcid":"0000-0002-5024-0817","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:08:28.266998Z","pmid":"36884349","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}