{"doi":"10.1016/j.celrep.2023.112147","title":"IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii","abstract":"Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii , but previous work has shown a limited role for endogenous IL-18 in control of this parasite. Although infection with T . gondii results in release of IL-18, the production of IFN-γ induces high levels of the IL-18 binding protein (IL-18BP). Antagonism of IL-18BP with a \"decoy-to-the-decoy\" (D2D) IL-18 construct that does not signal but rather binds IL-18BP results in enhanced innate lymphoid cell (ILC) and T cell responses and improved parasite control. In addition, the use of IL-18 resistant to IL-18BP (\"decoy-resistant\" IL-18 [DR-18]) is more effective than exogenous IL-18 at promoting innate resistance to infection. DR-18 enhances CD4 + T cell production of IFN-γ but results in CD4 + T cell-mediated pathology. Thus, endogenous IL-18BP restrains aberrant immune pathology, and this study highlights strategies that can be used to tune this regulatory pathway for optimal anti-pathogen responses.","journal":"Cell Reports","year":2023,"id":336958,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9451,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107007,"name":"Orr-El Weizman","orcid":"0000-0002-1132-8170","position":1,"is_corresponding":false},{"id":530708,"name":"Daniel L. Aldridge","orcid":"0000-0003-2224-5159","position":2,"is_corresponding":false},{"id":563022,"name":"Lindsey A. Shallberg","orcid":"0000-0001-6573-7327","position":3,"is_corresponding":false},{"id":987667,"name":"Julia Eberhard","orcid":"0009-0008-5134-9671","position":4,"is_corresponding":false},{"id":1021371,"name":"Zachary Lanzar","orcid":"0000-0001-7229-0973","position":5,"is_corresponding":false},{"id":1068317,"name":"Devon Wasche","orcid":null,"position":6,"is_corresponding":false},{"id":550018,"name":"John D. Huck","orcid":"0000-0002-0755-3850","position":7,"is_corresponding":false},{"id":231011,"name":"Ting Zhou","orcid":"0000-0001-8783-8380","position":8,"is_corresponding":false},{"id":17340,"name":"Aaron M. Ring","orcid":"0000-0003-3699-2446","position":9,"is_corresponding":false},{"id":305888,"name":"Christopher A. Hunter","orcid":"0000-0003-3092-1428","position":10,"is_corresponding":false},{"id":563025,"name":"Joseph T. Clark","orcid":"0000-0001-7764-6000","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T01:10:21.947540Z","pmid":"36827187","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}