{"doi":"10.1016/j.celrep.2023.111993","title":"N-glycosylated intestinal protein BCF-1 shapes microbial colonization by binding bacteria via its fimbrial protein","abstract":"Microbial colonization plays an instrumental role in the health of the host. However, the host factors that facilitate the establishment of the microbial colonization remain unclear. Here, we establish a screening method to identify host factors regulating E. coli colonization in C. elegans. We find that a BCF-1 possessing N-glycosylation promotes E. coli colonization by directly binding to E. coli via its fimbrial protein, YdeR. BCF-1 is activated by the bacteria and interacts with an oligosaccharyl transferase, OSTB-1, which is critical for regulating E. coli colonization. We also show that the N-glycosylation of BCF-1 is critical for E. coli colonization. In addition, we find that the microbiota composition is shaped by BCF-1. In summary, this study shows a \"scaffold model\" for bacterial colonization between a host glycoprotein and E. coli, and it also introduces a powerful research approach to identify individual host factors involved in modulating bacterial colonization.","journal":"Cell Reports","year":2023,"id":331865,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1057891,"name":"Fanrui Hao","orcid":null,"position":1,"is_corresponding":false},{"id":1057892,"name":"Herui Fu","orcid":null,"position":2,"is_corresponding":false},{"id":1057339,"name":"Guojing Tian","orcid":"0000-0001-5702-1142","position":3,"is_corresponding":false},{"id":1057893,"name":"Yingyang Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":1057340,"name":"Kai Fu","orcid":"0009-0002-7544-8582","position":5,"is_corresponding":false},{"id":1057341,"name":"Bin Qi","orcid":"0000-0003-2261-1550","position":6,"is_corresponding":false},{"id":1057890,"name":"Yongjuan He","orcid":null,"position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:09:25.015646Z","pmid":"36662624","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}