{"doi":"10.1016/j.celrep.2022.111963","title":"The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8+ T cell differentiation and function","abstract":"The Aryl hydrocarbon receptor (Ahr) regulates the differentiation and function of CD4 + T cells; however, its cell-intrinsic role in CD8 + T cells remains elusive. Herein we show that Ahr acts as a promoter of resident memory CD8 + T cell (T RM ) differentiation and function. Genetic ablation of Ahr in mouse CD8 + T cells leads to increased CD127 – KLRG1 + short-lived effector cells and CD44 + CD62L + T central memory cells but reduced granzyme-B-producing CD69 + CD103 + T RM cells. Genome-wide analyses reveal that Ahr suppresses the circulating while promoting the resident memory core gene program. A tumor resident polyfunctional CD8 + T cell population, revealed by single-cell RNA-seq, is diminished upon Ahr deletion, compromising anti-tumor immunity. Human intestinal intraepithelial CD8 + T cells also highly express AHR that regulates in vitro T RM differentiation and granzyme B production. Collectively, these data suggest that Ahr is an important cell-intrinsic factor for CD8 + T cell immunity.","journal":"Cell Reports","year":2023,"id":317530,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":631003,"name":"Eric Y. Helm","orcid":"0000-0001-6128-5204","position":1,"is_corresponding":false},{"id":307734,"name":"Zheng Fu","orcid":"0000-0002-0281-3043","position":2,"is_corresponding":false},{"id":307732,"name":"Lifeng Xiong","orcid":"0000-0001-5216-9236","position":3,"is_corresponding":false},{"id":1023075,"name":"Na Sun","orcid":"0000-0001-9653-3482","position":4,"is_corresponding":false},{"id":309768,"name":"Kristen N. Oliff","orcid":null,"position":5,"is_corresponding":false},{"id":1023623,"name":"Marcus Muehlbauer","orcid":null,"position":6,"is_corresponding":false},{"id":631013,"name":"Dorina Avram","orcid":"0000-0003-1254-1122","position":7,"is_corresponding":false},{"id":307738,"name":"Liang Zhou","orcid":"0000-0002-4644-7903","position":8,"is_corresponding":false},{"id":307733,"name":"Joseph Dean","orcid":"0000-0002-0239-3907","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T01:06:50.336418Z","pmid":"36640340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}