{"doi":"10.1016/j.celrep.2022.111904","title":"VGLL4 and MENIN function as TEAD1 corepressors to block pancreatic β cell proliferation","abstract":"TEAD1 and the mammalian Hippo pathway regulate cellular proliferation and function, though their regulatory function in β cells remains poorly characterized. In this study, we demonstrate that while β cell-specific TEAD1 deletion results in a cell-autonomous increase of β cell proliferation, β cell-specific deletion of its canonical coactivators, YAP and TAZ, does not affect proliferation, suggesting the involvement of other cofactors. Using an improved split-GFP system and yeast two-hybrid platform, we identify VGLL4 and MENIN as TEAD1 corepressors in β cells. We show that VGLL4 and MENIN bind to TEAD1 and repress the expression of target genes, including FZD7 and CCN2, which leads to an inhibition of β cell proliferation. In conclusion, we demonstrate that TEAD1 plays a critical role in β cell proliferation and identify VGLL4 and MENIN as TEAD1 corepressors in β cells. We propose that these could be targeted to augment proliferation in β cells for reversing diabetes.","journal":"Cell Reports","year":2023,"id":331863,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9463,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":564347,"name":"Ruya Liu","orcid":"0000-0003-1986-6800","position":1,"is_corresponding":false},{"id":469765,"name":"Vinny Negi","orcid":"0000-0003-3120-6952","position":2,"is_corresponding":false},{"id":1057335,"name":"Ping Yang","orcid":"0000-0003-2375-0616","position":3,"is_corresponding":false},{"id":330423,"name":"Jeongkyung Lee","orcid":null,"position":4,"is_corresponding":false},{"id":1057888,"name":"Rajaganapathi Jagannathan","orcid":null,"position":5,"is_corresponding":false},{"id":564353,"name":"Mousumi Moulik","orcid":"0009-0007-8705-4181","position":6,"is_corresponding":false},{"id":60611,"name":"Vijay Yechoor","orcid":"0000-0002-9981-6784","position":7,"is_corresponding":false},{"id":564349,"name":"Feng Li","orcid":"0000-0002-7063-9497","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T01:09:25.015646Z","pmid":"36662616","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}