{"doi":"10.1016/j.celrep.2022.111895","title":"PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection","abstract":"T cell-B cell interaction is the key immune response to protect the host from severe viral infection. However, how T cells support B cells to exert protective humoral immunity in humans is not well understood. Here, we use COVID-19 as a model of acute viral infections and analyze CD4 + T cell subsets associated with plasmablast expansion and clinical outcome. Peripheral helper T cells (Tph cells; denoted as PD-1 high CXCR5 – CD4 + T cells) are significantly increased, as are plasmablasts. Tph cells exhibit \"B cell help\" signatures and induce plasmablast differentiation in vitro . Interestingly, expanded plasmablasts show increased CXCR3 expression, which is positively correlated with higher frequency of activated Tph cells and better clinical outcome. Mechanistically, Tph cells help B cell differentiation and produce more interferon γ (IFNγ), which induces CXCR3 expression on plasmablasts. These results elucidate a role for Tph cells in regulating protective B cell response during acute viral infection.","journal":"Cell Reports","year":2023,"id":321308,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.958,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105802,"name":"Subhasis Mohanty","orcid":"0000-0002-3870-2468","position":1,"is_corresponding":false},{"id":555953,"name":"Michela Comi","orcid":"0000-0002-0109-4868","position":2,"is_corresponding":false},{"id":673515,"name":"William Ruff","orcid":"0000-0001-5828-6425","position":3,"is_corresponding":false},{"id":255166,"name":"Kenneth B. Hoehn","orcid":"0000-0003-0411-4307","position":4,"is_corresponding":false},{"id":105752,"name":"Patrick Wong","orcid":"0000-0002-1169-6395","position":5,"is_corresponding":false},{"id":105755,"name":"Jon Klein","orcid":"0000-0002-3552-7684","position":6,"is_corresponding":false},{"id":105754,"name":"Carolina Lucas","orcid":"0000-0003-4590-2756","position":7,"is_corresponding":false},{"id":673514,"name":"Inessa Cohen","orcid":"0000-0002-5807-2635","position":8,"is_corresponding":false},{"id":811149,"name":"Sarah Coffey","orcid":"0000-0003-3631-2228","position":9,"is_corresponding":false},{"id":1028146,"name":"Nikhil Lele","orcid":"0000-0001-7367-1364","position":10,"is_corresponding":false},{"id":1033974,"name":"Leissa Greta","orcid":null,"position":11,"is_corresponding":false},{"id":261878,"name":"Khadir Raddassi","orcid":"0000-0002-2383-9744","position":12,"is_corresponding":false},{"id":616788,"name":"Omkar Chaudhary","orcid":null,"position":13,"is_corresponding":false},{"id":555954,"name":"Avraham Unterman","orcid":"0000-0003-0965-3326","position":14,"is_corresponding":false},{"id":371392,"name":"Brinda Emu","orcid":"0000-0002-5784-9326","position":15,"is_corresponding":false},{"id":6493,"name":"Steven H. Kleinstein","orcid":"0000-0003-4957-1544","position":16,"is_corresponding":false},{"id":245127,"name":"Ruth R. Montgomery","orcid":"0000-0002-8661-4454","position":17,"is_corresponding":false},{"id":105840,"name":"Akiko Iwasaki","orcid":"0000-0002-7824-9856","position":18,"is_corresponding":false},{"id":105837,"name":"Charles S. Dela Cruz","orcid":"0000-0002-5258-1797","position":19,"is_corresponding":false},{"id":12162,"name":"Naftali Kaminski","orcid":"0000-0001-5917-4601","position":20,"is_corresponding":false},{"id":105833,"name":"Albert C. Shaw","orcid":"0000-0003-4970-7640","position":21,"is_corresponding":false},{"id":37332,"name":"David A. Hafler","orcid":"0000-0003-4664-535X","position":22,"is_corresponding":false},{"id":49152,"name":"Tomokazu S. Sumida","orcid":"0000-0002-9806-2642","position":23,"is_corresponding":false},{"id":622264,"name":"Hiromitsu Asashima","orcid":null,"position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"36596303","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}