{"doi":"10.1016/j.celrep.2022.111875","title":"Mitochondrial genome recovery by ATFS-1 is essential for development after starvation","abstract":"Nutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome (mtDNA) numbers and leads to aging-related phenotypes. Here we show that the bZIP (basic leucine zipper) protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPR mt ), is required to promote growth and establish a functional germline after prolonged starvation. We find that recovery of mtDNA copy numbers and development after starvation requires mitochondrion-localized ATFS-1 but not its nuclear transcription activity. We also find that the insulin-like receptor DAF-2 functions upstream of ATFS-1 to modulate mtDNA content. We show that reducing DAF-2 activity represses ATFS-1 nuclear function while causing an increase in mtDNA content, partly mediated by mitochondrion-localized ATFS-1. Our data indicate the importance of the UPR mt in recovering mitochondrial mass and suggest that atfs-1 -dependent mtDNA replication precedes mitochondrial network expansion after starvation.","journal":"Cell Reports","year":2022,"id":261679,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":634151,"name":"Sookyung Kim","orcid":"0000-0001-6674-940X","position":1,"is_corresponding":false},{"id":583471,"name":"Tomer Shpilka","orcid":"0000-0002-8339-9656","position":2,"is_corresponding":false},{"id":588035,"name":"Qiyuan Yang","orcid":"0000-0003-2992-5915","position":3,"is_corresponding":false},{"id":583949,"name":"Yunguang Du","orcid":null,"position":4,"is_corresponding":false},{"id":237112,"name":"Cole M. Haynes","orcid":"0000-0003-2110-5648","position":5,"is_corresponding":false},{"id":583952,"name":"Nandhitha Uma Naresh","orcid":null,"position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:26:16.663144Z","pmid":"36577367","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}