{"doi":"10.1016/j.celrep.2022.111846","title":"A single-cell atlas of murine reproductive tissues during preterm labor","abstract":"Preterm birth, the leading cause of perinatal morbidity and mortality worldwide, frequently results from the syndrome of preterm labor. The best-established causal link to preterm labor is intra-amniotic infection, which involves premature activation of the parturition cascade in the reproductive tissues. Herein, we utilize single-cell RNA sequencing (scRNA-seq) to generate a single-cell atlas of the murine uterus, decidua, and cervix in a model of infection-induced preterm labor. We show that preterm labor affects the transcriptomic profiles of specific immune and non-immune cell subsets. Shared and tissue-specific gene expression signatures are identified among affected cells. Determination of intercellular communications implicates specific cell types in preterm labor-associated signaling pathways across tissues. In silico comparison of murine and human uterine cell-cell interactions reveals conserved signaling pathways implicated in labor. Thus, our scRNA-seq data provide insights into the preterm labor-driven cellular landscape and communications in reproductive tissues.","journal":"Cell Reports","year":2023,"id":322325,"datarank":0.9382899788315517,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.38125416882590546,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.38125416882590546,"corpus_percentile":78.46368066836853,"corpus_rank":2785,"citation_count":40,"citer_count":35,"citers_with_citation_signal":23,"citers_with_endowment":23,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7717,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236857,"name":"Roberto Romero","orcid":"0000-0002-4448-5121","position":1,"is_corresponding":false},{"id":311663,"name":"Azam Peyvandipour","orcid":"0000-0002-8073-3348","position":2,"is_corresponding":false},{"id":275422,"name":"José Galaz","orcid":"0000-0002-8160-8581","position":3,"is_corresponding":false},{"id":804385,"name":"Errile Pusod","orcid":"0000-0002-2333-4746","position":4,"is_corresponding":false},{"id":438029,"name":"Bogdan Panaitescu","orcid":"0000-0003-4696-895X","position":5,"is_corresponding":false},{"id":275420,"name":"Derek Miller","orcid":"0000-0002-5812-7771","position":6,"is_corresponding":false},{"id":120720,"name":"Yi Xu","orcid":"0000-0001-8894-525X","position":7,"is_corresponding":false},{"id":586126,"name":"Tao Li","orcid":"0000-0003-1531-358X","position":8,"is_corresponding":false},{"id":843831,"name":"Zhenjie Liu","orcid":"0000-0003-1008-0043","position":9,"is_corresponding":false},{"id":236858,"name":"Adi L. Tarca","orcid":"0000-0003-1712-7588","position":10,"is_corresponding":false},{"id":65311,"name":"Roger Piqué-Regi","orcid":"0000-0002-1262-2275","position":11,"is_corresponding":false},{"id":236861,"name":"Nardhy Gomez‐Lopez","orcid":"0000-0002-3406-5262","position":12,"is_corresponding":false},{"id":275421,"name":"Valeria Garcia‐Flores","orcid":"0000-0003-3243-1780","position":0,"is_corresponding":true}],"reference_count":157,"raw_metadata":null,"created_at":"2026-07-19T01:07:42.497873Z","pmid":"36599348","pmcid":"PMC9946687","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}