{"doi":"10.1016/j.celrep.2022.111673","title":"A tick C1q protein alters infectivity of the Lyme disease agent by modulating interferon γ","abstract":"In North America, the Lyme disease agent, Borrelia burgdorferi , is commonly transmitted by the black-legged tick, Ixodes scapularis . Tick saliva facilitates blood feeding and enhances pathogen survival and transmission. Here, we demonstrate that I. scapularis complement C1q-like protein 3 (IsC1ql3), a tick salivary protein, directly interacts with B. burgdorferi and is important during the initial stage of spirochetal infection of mice. Mice fed upon by B. burgdorferi -infected IsC1ql3 -silenced ticks, or IsC1ql3-immunized mice fed upon by B. burgdorferi -infected ticks, have a lower spirochete burden during the early phase of infection compared with control animals. Mechanically, IsC1ql3 interacts with the globular C1q receptor present on the surface of CD4 + and CD8 + T cells, resulting in decreased production of interferon γ. IsC1ql3 is a C1q-domain-containing protein identified in arthropod vectors and has an important role in B. burgdorferi infectivity as the spirochete transitions from the tick to vertebrate host.","journal":"Cell Reports","year":2022,"id":256991,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":452637,"name":"Gunjan Arora","orcid":"0000-0003-0575-6205","position":1,"is_corresponding":false},{"id":906845,"name":"Jaqueline Matias","orcid":"0000-0002-8056-2825","position":2,"is_corresponding":false},{"id":703565,"name":"Thomas Hart","orcid":"0000-0001-5949-9932","position":3,"is_corresponding":false},{"id":303833,"name":"Yingjun Cui","orcid":"0000-0002-7416-0934","position":4,"is_corresponding":false},{"id":245049,"name":"Erol Fikrig","orcid":"0000-0002-5884-6047","position":5,"is_corresponding":false},{"id":761838,"name":"Xiaotian Tang","orcid":"0000-0002-0171-9354","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T00:25:30.183987Z","pmid":"36417869","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}