{"doi":"10.1016/j.celrep.2022.111641","title":"A dietary change to a high-fat diet initiates a rapid adaptation of the intestine","abstract":"Long-term impacts of diet have been well studied; however, the immediate response of the intestinal epithelium to a change in nutrients remains poorly understood. We use physiological metrics and single-cell transcriptomics to interrogate the intestinal epithelial cell response to a high-fat diet (HFD). Within 1 day of HFD exposure, mice exhibit altered whole-body physiology and increased intestinal epithelial proliferation. Single-cell transcriptional analysis on day 1 reveals a cell-stress response in intestinal crypts and a shift toward fatty acid metabolism. By 3 days of HFD, computational trajectory analysis suggests an emergence of progenitors, with a transcriptional profile shifting from secretory populations toward enterocytes. Furthermore, enterocytes upregulate lipid absorption genes and show increased lipid absorption in vivo over 7 days of HFD. These findings demonstrate the rapid intestinal epithelial response to a dietary change and help illustrate the essential ability of animals to adapt to shifting nutritional environments.","journal":"Cell Reports","year":2022,"id":235264,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":83,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":347802,"name":"Heather A. McCauley","orcid":"0000-0002-6834-4091","position":1,"is_corresponding":false},{"id":281129,"name":"Kevin Zhang","orcid":"0000-0002-6028-6536","position":2,"is_corresponding":false},{"id":349423,"name":"J. Guillermo Sanchez","orcid":null,"position":3,"is_corresponding":false},{"id":853851,"name":"Gregory T. Kalin","orcid":null,"position":4,"is_corresponding":false},{"id":281146,"name":"Richard A. Lang","orcid":"0000-0002-5212-254X","position":5,"is_corresponding":false},{"id":15871,"name":"James M. Wells","orcid":"0000-0002-1398-848X","position":6,"is_corresponding":false},{"id":347804,"name":"Jacob R. Enriquez","orcid":"0000-0002-5858-6759","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-19T00:21:48.116752Z","pmid":"36384107","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}