{"doi":"10.1016/j.celrep.2022.111629","title":"Oxaliplatin disrupts nucleolar function through biophysical disintegration","abstract":"Platinum (Pt) compounds such as oxaliplatin are among the most commonly prescribed anti-cancer drugs. Despite their considerable clinical impact, the molecular basis of platinum cytotoxicity and cancer specificity remain unclear. Here we show that oxaliplatin, a backbone for the treatment of colorectal cancer, causes liquid-liquid demixing of nucleoli at clinically relevant concentrations. Our data suggest that this biophysical defect leads to cell-cycle arrest, shutdown of Pol I-mediated transcription, and ultimately cell death. We propose that instead of targeting a single molecule, oxaliplatin preferentially partitions into nucleoli, where it modifies nucleolar RNA and proteins. This mechanism provides a general approach for drugging the increasing number of cellular processes linked to biomolecular condensates.","journal":"Cell Reports","year":2022,"id":237147,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":811887,"name":"Zane A. Jaafar","orcid":null,"position":1,"is_corresponding":false},{"id":859671,"name":"B. Erik Wulff","orcid":null,"position":2,"is_corresponding":false},{"id":731136,"name":"Jason Rodencal","orcid":"0000-0001-5637-611X","position":3,"is_corresponding":false},{"id":858896,"name":"Kibeom Hong","orcid":"0000-0002-7648-3761","position":4,"is_corresponding":false},{"id":858897,"name":"Mohammad Ovais Aziz-Zanjani","orcid":"0000-0003-4105-7102","position":5,"is_corresponding":false},{"id":84075,"name":"Peter K. Jackson","orcid":"0000-0002-1742-2539","position":6,"is_corresponding":false},{"id":109264,"name":"Manuel D. Leonetti","orcid":"0000-0002-4881-405X","position":7,"is_corresponding":false},{"id":90261,"name":"Scott J. Dixon","orcid":"0000-0001-6230-8199","position":8,"is_corresponding":false},{"id":312321,"name":"Rajat Rohatgi","orcid":"0000-0001-7609-8858","position":9,"is_corresponding":false},{"id":245625,"name":"Onn Brandman","orcid":"0000-0002-2084-154X","position":10,"is_corresponding":false},{"id":638149,"name":"Hermann Broder Schmidt","orcid":"0000-0002-0750-8419","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T00:22:08.925400Z","pmid":"36351392","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}