{"doi":"10.1016/j.celrep.2022.111611","title":"Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis","abstract":"Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an uncommon, but fatal, irAE caused after ICI treatments. Currently, the mechanism of ICI-associated myocarditis is unclear. Here, we show the development of myocarditis in A/J mice induced by anti-PD-1 monoclonal antibody (mAb) administration alone without tumor cell inoculation, immunization, or viral infection. Mice with myocarditis have increased cardiac infiltration, elevated cardiac troponin levels, and arrhythmia. Anti-PD-1 mAb treatment also causes irAEs in other organs. Autoimmune T cells recognizing cardiac myosin are activated and increased in mice with myocarditis. Notably, cardiac myosin-specific T cells are present in naive mice, showing a phenotype of antigen-experienced T cells. Collectively, we establish a clinically relevant mouse model for ICI-associated myocarditis and find a contribution of cardiac myosin-specific T cells to ICI-associated myocarditis development and pathogenesis.","journal":"Cell Reports","year":2022,"id":233735,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":118,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":848831,"name":"Hannah M. Kalinoski","orcid":null,"position":1,"is_corresponding":false},{"id":848044,"name":"Megan Kay Wood","orcid":"0000-0001-5176-8210","position":2,"is_corresponding":false},{"id":848045,"name":"David M. Hughes","orcid":"0000-0002-1287-9994","position":3,"is_corresponding":false},{"id":848832,"name":"Camille M. Jaime","orcid":null,"position":4,"is_corresponding":false},{"id":848833,"name":"Paul Delgado","orcid":null,"position":5,"is_corresponding":false},{"id":465559,"name":"Monica V. Talor","orcid":"0000-0002-8275-5698","position":6,"is_corresponding":false},{"id":494191,"name":"Ninaad Lasrado","orcid":"0000-0001-6762-2654","position":7,"is_corresponding":false},{"id":494196,"name":"Jay Reddy","orcid":"0000-0003-4082-9254","position":8,"is_corresponding":false},{"id":465563,"name":"Daniela Čiháková","orcid":"0000-0002-8713-2860","position":9,"is_corresponding":false},{"id":465557,"name":"Taejoon Won","orcid":"0000-0001-5968-2016","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T00:21:31.237180Z","pmid":"36351411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}