{"doi":"10.1016/j.celrep.2022.111585","title":"Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development","abstract":null,"journal":"Cell Reports","year":2022,"id":627268,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":725024,"name":"Xuanjia Fan","orcid":null,"position":1,"is_corresponding":false},{"id":1565744,"name":"Laura Sloofman","orcid":null,"position":2,"is_corresponding":false},{"id":572247,"name":"Lindsay Liang","orcid":"0000-0002-9393-2645","position":3,"is_corresponding":false},{"id":1623404,"name":"Enrico Mossotto","orcid":null,"position":4,"is_corresponding":false},{"id":1623405,"name":"Kendall Moore","orcid":null,"position":5,"is_corresponding":false},{"id":1414449,"name":"Sarah Zipkowitz","orcid":"0000-0003-1005-331X","position":6,"is_corresponding":false},{"id":744897,"name":"Minghui Wang","orcid":"0000-0003-2955-5344","position":7,"is_corresponding":false},{"id":1238484,"name":"Bin Zhang","orcid":"0000-0003-2606-5825","position":8,"is_corresponding":false},{"id":104392,"name":"Jiebiao Wang","orcid":"0000-0003-3828-4400","position":9,"is_corresponding":false},{"id":1623406,"name":"Nenad Sestan","orcid":null,"position":10,"is_corresponding":false},{"id":40215,"name":"Bernie Devlin","orcid":"0000-0003-2524-4290","position":11,"is_corresponding":false},{"id":40174,"name":"Kathryn Roeder","orcid":"0000-0002-8869-6254","position":12,"is_corresponding":false},{"id":1623407,"name":"Stephan J. Sanders","orcid":null,"position":13,"is_corresponding":false},{"id":35461,"name":"Joseph D. Buxbaum","orcid":"0000-0001-8898-8313","position":14,"is_corresponding":false},{"id":35432,"name":"Michael S. Breen","orcid":"0000-0002-6739-939X","position":15,"is_corresponding":false},{"id":1623402,"name":"Winston H. Dredge","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development","abstract":"Posttranscriptional RNA modifications by adenosine-to-inosine (A-to-I) editing are abundant in the brain, yet elucidating functional sites remains challenging. To bridge this gap, we investigate spatiotemporal and genetically regulated A-to-I editing sites across prenatal and postnatal stages of human brain development. More than 10,000 spatiotemporally regulated A-to-I sites were identified that occur predominately in 3' UTRs and introns, as well as 37 sites that recode amino acids in protein coding regions with precise changes in editing levels across development. Hyper-edited transcripts are also enriched in the aging brain and stabilize RNA secondary structures. These features are conserved in murine and non-human primate models of neurodevelopment. Finally, thousands of cis-editing quantitative trait loci (edQTLs) were identified with unique regulatory effects during prenatal and postnatal development. Collectively, this work offers a resolved atlas linking spatiotemporal variation in editing levels to genetic regulatory effects throughout distinct stages of brain maturation.","is_dataset_classified":null,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36323256","pmcid":"PMC9704047","openalex_id":"https://openalex.org/W4308037687","authors":[],"funders":[{"funder_name":"Icahn School of Medicine at Mount Sinai","grant_id":"R01MH111679","title":null},{"funder_name":"Icahn School of Medicine at Mount Sinai","grant_id":"R01MH129724","title":null},{"funder_name":"National Institute on Aging","grant_id":"RF1AG057440","title":null},{"funder_name":"National Institute on Aging","grant_id":"U01AG046170","title":null},{"funder_name":"National Institute on Aging","grant_id":"U01AG052411","title":null},{"funder_name":"National Institute of Mental Health","grant_id":"U01MH122678","title":null},{"funder_name":"NIA NIH HHS","grant_id":"RF1 AG059319","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH123184","title":null},{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH129725","title":null},{"funder_name":"National Institutes of Health","grant_id":"1RF1AG057440-01","title":"Towards a comprehensive signaling pathway map of parahippocampal vulnerability in Alzheimers Disease"},{"funder_name":"National Institutes of Health","grant_id":"1R01MH111679-01A1","title":"Large-scale reprogramming and expression analysis of patient-derived neural cells in schizophrenia"},{"funder_name":"National Institutes of Health","grant_id":"1U01MH122678-01","title":"1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development"},{"funder_name":"National Institutes of Health","grant_id":"5U01AG052411-03","title":"Identification and characterization of AD risk networks using multi-dimensional \"omics\" data"},{"funder_name":"National Institutes of Health","grant_id":"3U01AG046170-01S1","title":"Accelerating Medicine Partnership in Alzheimer's Disease: Enabling collaborative"},{"funder_name":"National Institutes of Health","grant_id":"5R01MH129724-04","title":"1/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder"},{"funder_name":"Yale University","grant_id":"","title":null}],"total_grants":16,"fwci":2.3528,"citation_percentile":0.8988822,"influential_citations":0,"citation_trend":[{"year":2022,"count":1},{"year":2023,"count":6},{"year":2024,"count":14},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.celrep.2022.111585","host_type":"journal"},{"url":"https://doi.org/10.1016/j.celrep.2022.111585","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124722014504?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124722014504?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36323256","host_type":"repository"},{"url":"https://escholarship.org/uc/item/3wk5480j","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9704047","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9704047","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9704047?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.celrep.2022.111585","host_type":""},{"url":"https://escholarship.org/content/qt3wk5480j/qt3wk5480j.pdf","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.celrep.2022.111585","host_type":""}],"fields_of_study":["RNA regulation and disease","RNA Research and Splicing","RNA modifications and cancer","0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":["Adenosine","Adenosine Deaminase","Animals","Brain","Humans","Inosine","Primates","RNA Editing","3' Untranslated Regions","Mice"],"keywords":["RNA editing","Biology","ADAR","Inosine","Computational biology","RNA","Genetics","Evolutionary biology","Gene","Adenosine","Brain Maturation","Rna Modifications","Hyper-editing","Rna Recoding","Cp: Molecular Biology","Cp: Neuroscience","Edqtls","Late-fetal Transition","Primates","570","Adenosine Deaminase","1.1 Normal biological development and functioning","Medical Physiology","Bioinformatics and Computational Biology","610","Article","Mice","Underpinning research","Humans","Animals","3' Untranslated Regions","Pediatric","Neurosciences","Brain","Biological Sciences","Neurological","Congenital Structural Anomalies","Biochemistry and Cell Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"},{"name":"bioproject"},{"name":"gen"},{"name":"arrayexpress"},{"name":"refsnp"},{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T16:53:41.777934Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}