{"doi":"10.1016/j.celrep.2022.111547","title":"Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting","abstract":"While intermittent fasting is a safe strategy to benefit health, it remains unclear whether a \"timer\" exists in vivo to record fasting duration and trigger a transcriptional switch. Here, we map a circadian transcriptional pathway atlas from 600 samples across four metabolic tissues of mice under five feeding regimens. Results show that 95.6% of detected canonical pathways are rhythmic in a tissue-specific and feeding-regimen-specific manner, while only less than 25% of them induce changes in transcriptional function. Fasting for 16 h initiates a circadian resonance of 43 pathways in the liver, and the resonance punctually switches following refeeding. The hepatic proteasome coordinates the resonance, and most genes encoding proteasome subunits display a 16-h fasting-dependent transcriptional switch. These findings indicate that the hepatic proteasome may serve as a fasting timer and a coordinator of pathway transcriptional resonance, which provide a target for revealing the underlying mechanism of intermittent fasting.","journal":"Cell Reports","year":2022,"id":275904,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9248,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":945966,"name":"Lijun Gong","orcid":"0009-0006-5790-2461","position":1,"is_corresponding":false},{"id":945967,"name":"Siyu Lu","orcid":"0000-0002-4735-0425","position":2,"is_corresponding":false},{"id":945968,"name":"Yiming Zhou","orcid":"0000-0003-0205-9922","position":3,"is_corresponding":false},{"id":945969,"name":"Li Liu","orcid":"0000-0002-0504-418X","position":4,"is_corresponding":false},{"id":945970,"name":"Zhigui Duan","orcid":"0000-0002-3452-9805","position":5,"is_corresponding":false},{"id":945971,"name":"Rong Xiang","orcid":"0000-0003-0651-5446","position":6,"is_corresponding":false},{"id":281044,"name":"Frank J. Gonzalez","orcid":"0000-0002-7990-2140","position":7,"is_corresponding":false},{"id":945972,"name":"Guolin Li","orcid":"0000-0002-8862-3928","position":8,"is_corresponding":false},{"id":506000,"name":"Fang Wei","orcid":"0000-0002-8392-3243","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T00:28:26.545826Z","pmid":"36288692","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}