{"doi":"10.1016/j.celrep.2022.111514","title":"Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis","abstract":"We identify ADIRF-AS1 circadian long non-coding RNA (lncRNA). Deletion of ADIRF-AS1 in U2OS cells alters rhythmicity of clock-controlled genes and expression of extracellular matrix genes. ADIRF-AS1 interacts with all components of the PBAF (PBRM1/BRG1) complex in U2OS cells. Because PBRM1 is a tumor suppressor mutated in over 40% of clear cell renal carcinoma (ccRCC) cases, we evaluate ADIRF-AS1 in ccRCC cells. Reducing ADIRF-AS1 expression in ccRCC cells decreases expression of some PBAF-suppressed genes. Expression of these genes is partially rescued by PBRM1 loss, consistent with ADIRF-AS1 acting in part to modulate PBAF. ADIRF-AS1 expression correlates with survival in human ccRCC, particularly in PBRM1 wild-type, but not mutant, tumors. Loss of ADIRF-AS1 eliminates in vivo tumorigenesis, partially rescued by concurrent loss of PBRM1 only when co-injected with Matrigel, suggesting a PBRM1-independent function of ADIRF-AS1. Our findings suggest that ADIRF-AS1 functions partly through PBAF to regulate specific genes as a BMAL1-CLOCK-regulated, oncogenic lncRNA.","journal":"Cell Reports","year":2022,"id":261431,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9556,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":916803,"name":"Judith Monzy","orcid":null,"position":1,"is_corresponding":false},{"id":818194,"name":"Bailey Aaron","orcid":"0000-0003-4492-8866","position":2,"is_corresponding":false},{"id":772399,"name":"Xue Zhang","orcid":"0000-0003-0940-037X","position":3,"is_corresponding":false},{"id":245076,"name":"Andrew V. Kossenkov","orcid":"0000-0002-1536-0418","position":4,"is_corresponding":false},{"id":625174,"name":"James E. Hayden","orcid":"0000-0002-5491-2975","position":5,"is_corresponding":false},{"id":626660,"name":"Frederick Keeney","orcid":null,"position":6,"is_corresponding":false},{"id":258005,"name":"David W. Speicher","orcid":"0000-0003-1311-4261","position":7,"is_corresponding":false},{"id":255357,"name":"Lin Zhang","orcid":"0000-0003-1998-0611","position":8,"is_corresponding":false},{"id":7940,"name":"Chi V. Dang","orcid":"0000-0002-4031-2522","position":9,"is_corresponding":false},{"id":649494,"name":"Rebekah Brooks","orcid":"0000-0002-9795-5748","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T00:26:16.663144Z","pmid":"36261012","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}