{"doi":"10.1016/j.celrep.2022.111390","title":"Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin","abstract":"Preservation of a small population of cancer stem cells (CSCs) within a heterogeneous carcinoma serves as a paradigm to understand how select cells in a tissue maintain their undifferentiated status. In both embryogenesis and cancer, Snail has been correlated with stemness, but the molecular underpinning of this phenomenon remains largely ill-defined. In models of cutaneous squamous cell carcinoma (cSCC), we discovered a non-epithelial-mesenchymal transition function for the transcription factor Snail in maintaining the stemness of epidermal keratinocytes. Snail-expressing cells secrete the matricellular protein Mindin, which functions in an autocrine fashion to activate a Src-STAT3 pathway to reinforce their stem/progenitor phenotype. This pathway is activated by the engagement of Mindin with the leukocyte-specific integrin, CD11b (ITGAM), which is also unexpectedly expressed by epidermal keratinocytes. Interestingly, disruption of this signaling module in human cSCC attenuates tumorigenesis, suggesting that targeting Mindin would be a promising therapeutic approach to hinder cancer recurrence.","journal":"Cell Reports","year":2022,"id":270380,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":820866,"name":"Binita Dam","orcid":"0000-0003-1684-4614","position":1,"is_corresponding":false},{"id":820867,"name":"Sunny Kataria","orcid":"0000-0002-0690-6300","position":2,"is_corresponding":false},{"id":820868,"name":"Ravindra K. Zirmire","orcid":"0000-0002-6003-2771","position":3,"is_corresponding":false},{"id":820869,"name":"Rakesh Dey","orcid":"0000-0002-8258-2969","position":4,"is_corresponding":false},{"id":918661,"name":"Gaurav Kansagara","orcid":"0000-0003-0779-3165","position":5,"is_corresponding":false},{"id":918657,"name":"Johan Ajnabi","orcid":"0000-0002-9437-9300","position":6,"is_corresponding":false},{"id":934203,"name":"Akshay Hegde","orcid":"0000-0002-6800-3828","position":7,"is_corresponding":false},{"id":819221,"name":"Randhir Singh","orcid":"0000-0001-7388-225X","position":8,"is_corresponding":false},{"id":820870,"name":"Tafheem Masudi","orcid":"0000-0001-7406-9084","position":9,"is_corresponding":false},{"id":821153,"name":"Janani Sambath","orcid":null,"position":10,"is_corresponding":false},{"id":934619,"name":"Sasikala P. Sachithanandan","orcid":null,"position":11,"is_corresponding":false},{"id":934204,"name":"Prashant Kumar","orcid":"0000-0001-8975-5108","position":12,"is_corresponding":false},{"id":612928,"name":"Akash Gulyani","orcid":"0000-0003-4130-4257","position":13,"is_corresponding":false},{"id":782816,"name":"You‐Wen He","orcid":"0000-0002-8983-2684","position":14,"is_corresponding":false},{"id":820872,"name":"Sudhir Krishna","orcid":"0000-0002-0444-531X","position":15,"is_corresponding":false},{"id":820873,"name":"Colin Jamora","orcid":"0000-0003-2127-2972","position":16,"is_corresponding":false},{"id":820865,"name":"Krithika Badarinath","orcid":"0000-0003-0941-5504","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-19T00:27:26.772098Z","pmid":"36130502","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}