{"doi":"10.1016/j.celrep.2022.111345","title":"Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation","abstract":"Th17 cells enhances IL-17 expression and colitis severity. Mechanistically, we demonstrate that Pak2-mediated phosphorylation causes a conformational change resulting in exposure of the ubiquitin ligase Itch interacting PPLY motif and degradation of RORγt. Thus, we have uncovered a mechanism by which the activity of RORγt is regulated that can be exploited therapeutically.","journal":"Cell Reports","year":2022,"id":274401,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":626345,"name":"Ritesh Kumar","orcid":"0000-0002-0150-8880","position":1,"is_corresponding":false},{"id":943485,"name":"Elviche Taskem lenou","orcid":null,"position":2,"is_corresponding":false},{"id":253569,"name":"Venkatesha Basrur","orcid":"0000-0002-0853-9655","position":3,"is_corresponding":false},{"id":266693,"name":"Arianne L. Theiss","orcid":"0000-0003-2862-0933","position":4,"is_corresponding":false},{"id":343747,"name":"Jonathan Chernoff","orcid":"0000-0002-4803-7836","position":5,"is_corresponding":false},{"id":269153,"name":"K. Venuprasad","orcid":null,"position":6,"is_corresponding":false},{"id":371928,"name":"Mahesh Kathania","orcid":"0000-0002-4784-8581","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:28:12.324621Z","pmid":"36103814","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}