{"doi":"10.1016/j.celrep.2022.111264","title":"Chimpanzee and pig-tailed macaque iPSCs: Improved culture and generation of primate cross-species embryos","abstract":"As our closest living relatives, non-human primates uniquely enable explorations of human health, disease, development, and evolution. Considerable effort has thus been devoted to generating induced pluripotent stem cells (iPSCs) from multiple non-human primate species. Here, we establish improved culture methods for chimpanzee (Pan troglodytes) and pig-tailed macaque (Macaca nemestrina) iPSCs. Such iPSCs spontaneously differentiate in conventional culture conditions, but can be readily propagated by inhibiting endogenous WNT signaling. As a unique functional test of these iPSCs, we injected them into the pre-implantation embryos of another non-human species, rhesus macaques (Macaca mulatta). Ectopic expression of gene BCL2 enhances the survival and proliferation of chimpanzee and pig-tailed macaque iPSCs within the pre-implantation embryo, although the identity and long-term contribution of the transplanted cells warrants further investigation. In summary, we disclose transcriptomic and proteomic data, cell lines, and cell culture resources that may be broadly enabling for non-human primate iPSCs research.","journal":"Cell Reports","year":2022,"id":259002,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9439,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":189719,"name":"Fabian Suchy","orcid":"0000-0002-7187-5360","position":1,"is_corresponding":false},{"id":409609,"name":"Lan Huong Nguyen","orcid":"0000-0003-3397-0380","position":2,"is_corresponding":false},{"id":911075,"name":"Vivek K. Bajpai","orcid":"0000-0003-0423-6195","position":3,"is_corresponding":false},{"id":74107,"name":"Rahul Sinha","orcid":"0000-0001-7511-0798","position":4,"is_corresponding":false},{"id":427890,"name":"José G. Vilches-Moure","orcid":"0000-0003-3341-2258","position":5,"is_corresponding":false},{"id":574506,"name":"Kevin Van Bortle","orcid":"0000-0003-0733-0830","position":6,"is_corresponding":false},{"id":576966,"name":"Joydeep Bhadury","orcid":"0000-0002-4333-9974","position":7,"is_corresponding":false},{"id":227304,"name":"Ahmed A. Metwally","orcid":"0000-0002-0155-7412","position":8,"is_corresponding":false},{"id":618595,"name":"Lihua Jiang","orcid":"0000-0002-4690-1408","position":9,"is_corresponding":false},{"id":49820,"name":"Ruiqi Jian","orcid":"0000-0003-2406-5303","position":10,"is_corresponding":false},{"id":179247,"name":"Rosaria Chiang","orcid":null,"position":11,"is_corresponding":false},{"id":440676,"name":"Angelos Oikonomopoulos","orcid":null,"position":12,"is_corresponding":false},{"id":12998,"name":"Joseph C. Wu","orcid":"0000-0002-6068-8041","position":13,"is_corresponding":false},{"id":29969,"name":"Irving L. Weissman","orcid":"0000-0002-9077-7467","position":14,"is_corresponding":false},{"id":409612,"name":"Joseph L. Mankowski","orcid":"0000-0002-6283-4727","position":15,"is_corresponding":false},{"id":31864,"name":"Susan Holmes","orcid":"0000-0002-2208-8168","position":16,"is_corresponding":false},{"id":274575,"name":"Kyle M. Loh","orcid":"0000-0002-8042-0149","position":17,"is_corresponding":false},{"id":189721,"name":"Hiromitsu Nakauchi","orcid":"0000-0002-9841-6973","position":18,"is_corresponding":false},{"id":607009,"name":"Catherine A. VandeVoort","orcid":"0000-0002-9535-9555","position":19,"is_corresponding":false},{"id":5648,"name":"Michael P. Snyder","orcid":"0000-0003-0784-7987","position":20,"is_corresponding":false},{"id":409608,"name":"Morteza Roodgar","orcid":"0000-0002-2995-6124","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T00:25:47.305414Z","pmid":"36044843","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}