{"doi":"10.1016/j.celrep.2022.111094","title":"A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever","abstract":"Lassa virus (LASV) is recognized by the World Health Organization as one of the top five pathogens likely to cause a severe outbreak. A recent unprecedented resurgence of LASV in Nigeria caused by genetically diverse strains underscores the need for licensed medical countermeasures. Single-injection vaccines that can rapidly control outbreaks and confer long-term immunity are needed. Vaccination of cynomolgus monkeys with a recombinant vesicular stomatitis virus vector expressing the glycoprotein precursor of LASV lineage IV strain Josiah (rVSVΔG-LASV-GPC) induces fast-acting protection in monkeys challenged 3 or 7 days later with a genetically heterologous lineage II isolate of LASV from Nigeria, while nonspecifically vaccinated control animals succumb to challenge. The rVSVΔG-LASV-GPC vaccine induces rapid activation of adaptive immunity and the transcription of natural killer (NK) cell-affiliated mRNAs. This study demonstrates that rVSVΔG-LASV-GPC may provide rapid protection in humans against LASV infections in cases where immediate public-health intervention is required.","journal":"Cell Reports","year":2022,"id":239792,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242843,"name":"Courtney Woolsey","orcid":"0000-0003-3389-0137","position":1,"is_corresponding":false},{"id":242844,"name":"Abhishek N. Prasad","orcid":"0000-0002-4147-2077","position":2,"is_corresponding":false},{"id":124945,"name":"Viktoriya Borisevich","orcid":null,"position":3,"is_corresponding":false},{"id":242845,"name":"Krystle N. Agans","orcid":"0000-0002-7319-6935","position":4,"is_corresponding":false},{"id":242846,"name":"Daniel J. Deer","orcid":"0009-0005-4744-8560","position":5,"is_corresponding":false},{"id":244154,"name":"Joan B. Geisbert","orcid":null,"position":6,"is_corresponding":false},{"id":242847,"name":"Natalie S. Dobias","orcid":"0009-0000-7352-5885","position":7,"is_corresponding":false},{"id":242851,"name":"Karla A. Fenton","orcid":"0000-0002-5530-6969","position":8,"is_corresponding":false},{"id":242852,"name":"Thomas W. Geisbert","orcid":"0000-0003-0858-1877","position":9,"is_corresponding":false},{"id":242853,"name":"Robert W. Cross","orcid":"0000-0001-7718-1522","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:22:41.699779Z","pmid":"35858566","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}