{"doi":"10.1016/j.celrep.2022.111028","title":"Running speed and REM sleep control two distinct modes of rapid interhemispheric communication","abstract":"Rhythmic gamma-band communication within and across cortical hemispheres is critical for optimal perception, navigation, and memory. Here, using multisite recordings in both rats and mice, we show that even faster ∼140 Hz rhythms are robustly anti-phase across cortical hemispheres, visually resembling splines, the interlocking teeth on mechanical gears. Splines are strongest in superficial granular retrosplenial cortex, a region important for spatial navigation and memory. Spline-frequency interhemispheric communication becomes more coherent and more precisely anti-phase at faster running speeds. Anti-phase splines also demarcate high-activity frames during REM sleep. While splines and associated neuronal spiking are anti-phase across retrosplenial hemispheres during navigation and REM sleep, gamma-rhythmic interhemispheric communication is precisely in-phase. Gamma and splines occur at distinct points of a theta cycle and thus highlight the ability of interhemispheric cortical communication to rapidly switch between in-phase (gamma) and anti-phase (spline) modes within individual theta cycles during both navigation and REM sleep.","journal":"Cell Reports","year":2022,"id":258821,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":910430,"name":"Fang‐Chi Yang","orcid":"0000-0002-3067-3092","position":1,"is_corresponding":false},{"id":562487,"name":"Sharena P. Rice","orcid":null,"position":2,"is_corresponding":false},{"id":910892,"name":"Vaughn L. Hetrick","orcid":null,"position":3,"is_corresponding":false},{"id":428340,"name":"Alcides Lorenzo Gonzalez","orcid":"0000-0002-8633-2692","position":4,"is_corresponding":false},{"id":910431,"name":"Danny Siu","orcid":"0000-0003-0742-233X","position":5,"is_corresponding":false},{"id":562485,"name":"Ellen K.W. Brennan","orcid":null,"position":6,"is_corresponding":false},{"id":568413,"name":"Tibin T. John","orcid":"0000-0002-6825-7166","position":7,"is_corresponding":false},{"id":485587,"name":"Allison M. Ahrens","orcid":null,"position":8,"is_corresponding":false},{"id":449291,"name":"Omar J. Ahmed","orcid":"0000-0003-3300-7658","position":9,"is_corresponding":false},{"id":449288,"name":"Megha Ghosh","orcid":"0000-0002-8230-3149","position":0,"is_corresponding":true}],"reference_count":134,"raw_metadata":null,"created_at":"2026-07-19T00:25:43.037820Z","pmid":"35793619","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}