{"doi":"10.1016/j.celrep.2022.110961","title":"Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice","abstract":"Microglia are strongly implicated in the development and progression of Alzheimer's disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetically lacks microglia. The resulting microglial-deficient mice exhibit a profound shift from parenchymal amyloid plaques to cerebral amyloid angiopathy (CAA), which is accompanied by numerous transcriptional changes, greatly increased brain calcification and hemorrhages, and premature lethality. Remarkably, a single injection of wild-type microglia into adult mice repopulates the microglial niche and prevents each of these pathological changes. Taken together, these results indicate the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification. To further understand the clinical implications of these findings, human AD tissue and iPSC-microglia were examined, providing evidence that microglia phagocytose calcium crystals, and this process is impaired by loss of the AD risk gene, TREM2.","journal":"Cell Reports","year":2022,"id":232573,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":184,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":551832,"name":"Samuel Morabito","orcid":"0000-0002-7768-4856","position":1,"is_corresponding":false},{"id":234236,"name":"Emma Danhash","orcid":null,"position":2,"is_corresponding":false},{"id":231729,"name":"Amanda McQuade","orcid":"0000-0001-5368-6788","position":3,"is_corresponding":false},{"id":844813,"name":"Jessica Sanchez","orcid":null,"position":4,"is_corresponding":false},{"id":656429,"name":"Emily Miyoshi","orcid":"0000-0001-8151-0560","position":5,"is_corresponding":false},{"id":231735,"name":"Jean Paul Chadarevian","orcid":"0000-0002-2478-6592","position":6,"is_corresponding":false},{"id":623720,"name":"Christel Claes","orcid":"0000-0002-7765-0445","position":7,"is_corresponding":false},{"id":231733,"name":"Morgan Coburn","orcid":"0000-0003-4888-1671","position":8,"is_corresponding":false},{"id":231731,"name":"Jonathan Hasselmann","orcid":"0000-0003-2630-9850","position":9,"is_corresponding":false},{"id":624734,"name":"Jorge Luis Silva Hidalgo","orcid":null,"position":10,"is_corresponding":false},{"id":844814,"name":"Kayla Nhi Tran","orcid":null,"position":11,"is_corresponding":false},{"id":315606,"name":"Alessandra Cadete Martini","orcid":"0000-0002-8447-6756","position":12,"is_corresponding":false},{"id":843576,"name":"Winston Chang Rothermich","orcid":"0000-0003-1866-8124","position":13,"is_corresponding":false},{"id":843577,"name":"Jesse R. Pascual","orcid":"0000-0002-3307-0887","position":14,"is_corresponding":false},{"id":270466,"name":"Elizabeth Head","orcid":"0000-0003-1115-6396","position":15,"is_corresponding":false},{"id":24164,"name":"David Hume","orcid":"0000-0002-2615-1478","position":16,"is_corresponding":false},{"id":843578,"name":"Clare Pridans","orcid":"0000-0001-9423-557X","position":17,"is_corresponding":false},{"id":231744,"name":"Hayk Davtyan","orcid":"0000-0001-8554-6456","position":18,"is_corresponding":false},{"id":27831,"name":"Vivek Swarup","orcid":"0000-0003-3762-2746","position":19,"is_corresponding":false},{"id":7841,"name":"Mathew Blurton-Jones","orcid":"0000-0002-7770-7157","position":20,"is_corresponding":false},{"id":231734,"name":"Sepideh Kiani Shabestari","orcid":"0000-0002-2840-116X","position":0,"is_corresponding":true}],"reference_count":92,"raw_metadata":null,"created_at":"2026-07-19T00:21:18.683916Z","pmid":"35705056","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}