{"doi":"10.1016/j.celrep.2022.110938","title":"Single-cell RNA sequencing reveals immunological rewiring at the maternal-fetal interface following asymptomatic/mild SARS-CoV-2 infection","abstract":"While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua in response to asymptomatic/mild disease in pregnant women. We report attenuated antigen presentation and type I interferon (IFN) signaling pathways, loss of tissue-resident decidual macrophages, and upregulated cytokine/chemokine signaling in monocyte-derived decidual macrophages. Furthermore, we describe increased frequencies of activated tissue-resident T cells and decreased abundance of regulatory T cells with infection while frequencies of cytotoxic CD4/CD8 T cells are increased in the blood. In contrast to decidual macrophages, type I IFN signaling is higher in decidual T cells. Finally, infection leads to a narrowing of T cell receptor diversity in both blood and decidua. Collectively, these observations indicate that asymptomatic/mild COVID-19 during pregnancy results in remodeling of the immunological landscape of the maternal-fetal interface, with a potential for long-term adverse outcomes for the offspring.","journal":"Cell Reports","year":2022,"id":246525,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":572364,"name":"Michael Z. Zulu","orcid":"0000-0002-3203-7866","position":1,"is_corresponding":false},{"id":640093,"name":"Brianna M. Doratt","orcid":"0000-0002-8107-724X","position":2,"is_corresponding":false},{"id":366004,"name":"Allen Jankeel","orcid":"0000-0003-1316-1332","position":3,"is_corresponding":false},{"id":522461,"name":"Delia F. Tifrea","orcid":"0000-0002-7531-9337","position":4,"is_corresponding":false},{"id":347748,"name":"Robert A. Edwards","orcid":"0000-0001-9145-382X","position":5,"is_corresponding":false},{"id":426754,"name":"Mónica Rincón","orcid":"0000-0001-5574-585X","position":6,"is_corresponding":false},{"id":523548,"name":"Nicole Marshall","orcid":"0000-0003-3105-555X","position":7,"is_corresponding":false},{"id":366007,"name":"Ilhem Messaoudi","orcid":"0000-0003-3203-2405","position":8,"is_corresponding":false},{"id":501722,"name":"Suhas Sureshchandra","orcid":"0000-0002-4141-8564","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:23:48.622830Z","pmid":"35662411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}