{"doi":"10.1016/j.celrep.2022.110817","title":"Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila","abstract":"Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of the remaining eight Toll-related proteins in Drosophila are not fully understood. Here, we show that Drosophila Toll-9 is necessary and sufficient for a special form of compensatory proliferation after apoptotic cell loss (undead apoptosis-induced proliferation [AiP]). Mechanistically, for AiP, Toll-9 interacts with Toll-1 to activate the intracellular Toll-1 pathway for nuclear translocation of the NF-κB-like transcription factor Dorsal, which induces expression of the pro-apoptotic genes reaper and hid. This activity contributes to the feedback amplification loop that operates in undead cells. Given that Toll-9 also functions in loser cells during cell competition, we define a general role of Toll-9 in cellular stress situations leading to the expression of pro-apoptotic genes that trigger apoptosis and apoptosis-induced processes such as AiP. This work identifies conceptual similarities between cell competition and AiP.","journal":"Cell Reports","year":2022,"id":244546,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252758,"name":"Alla Amcheslavsky","orcid":null,"position":1,"is_corresponding":false},{"id":344577,"name":"Elizabeth Brown","orcid":"0000-0003-0825-8199","position":2,"is_corresponding":false},{"id":234499,"name":"Tom V. Lee","orcid":null,"position":3,"is_corresponding":false},{"id":584832,"name":"Yingchao Nie","orcid":"0000-0001-6151-0811","position":4,"is_corresponding":false},{"id":585281,"name":"Takahiro Tanji","orcid":null,"position":5,"is_corresponding":false},{"id":246166,"name":"Y. Tony Ip","orcid":"0000-0003-4370-7906","position":6,"is_corresponding":false},{"id":300680,"name":"Andreas Bergmann","orcid":"0000-0002-9134-871X","position":7,"is_corresponding":false},{"id":584831,"name":"Alicia Shields","orcid":"0000-0002-0280-7188","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-19T00:23:30.364338Z","pmid":"35584678","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}