{"doi":"10.1016/j.celrep.2022.110814","title":"WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC","abstract":"cytotoxic T cell infiltration. We further show that WEE1 inhibition concomitantly activates the STAT1 pathway, increasing IFN-γ and PD-L1 expression. Consistent with these findings, combined WEE1 inhibition (AZD1775) and PD-L1 blockade causes remarkable tumor regression, activation of type I and II interferon pathways, and infiltration of cytotoxic T cells in multiple immunocompetent SCLC genetically engineered mouse models, including an aggressive model with stabilized MYC. Our study demonstrates cell-autonomous and immune-stimulating activity of WEE1 inhibition in SCLC models. Combined inhibition of WEE1 plus PD-L1 blockade represents a promising immunotherapeutic approach in SCLC.","journal":"Cell Reports","year":2022,"id":233302,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":134,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9462,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":573866,"name":"Rebecca Caeser","orcid":"0000-0002-8416-9844","position":1,"is_corresponding":false},{"id":231582,"name":"Shweta S. Chavan","orcid":"0000-0001-9433-6936","position":2,"is_corresponding":false},{"id":553862,"name":"Yingqian A. Zhan","orcid":"0000-0002-3548-9227","position":3,"is_corresponding":false},{"id":297331,"name":"Andrew Chow","orcid":"0000-0003-1151-2450","position":4,"is_corresponding":false},{"id":640075,"name":"Parvathy Manoj","orcid":"0000-0002-1121-0121","position":5,"is_corresponding":false},{"id":229270,"name":"Fathema Uddin","orcid":null,"position":6,"is_corresponding":false},{"id":846170,"name":"Hidenori Kitai","orcid":"0000-0001-6372-846X","position":7,"is_corresponding":false},{"id":671916,"name":"Rui Qu","orcid":"0000-0002-2716-6401","position":8,"is_corresponding":false},{"id":238380,"name":"Omar Hayatt","orcid":"0009-0007-7453-5621","position":9,"is_corresponding":false},{"id":65357,"name":"Nisargbhai Shah","orcid":"0000-0002-0214-4919","position":10,"is_corresponding":false},{"id":847175,"name":"Álvaro Quintanal Villalonga","orcid":null,"position":11,"is_corresponding":false},{"id":229185,"name":"Viola Allaj","orcid":null,"position":12,"is_corresponding":false},{"id":846171,"name":"Evelyn M. Nguyen","orcid":"0000-0002-0809-1870","position":13,"is_corresponding":false},{"id":225134,"name":"Joseph M. Chan","orcid":"0000-0001-5249-7395","position":14,"is_corresponding":false},{"id":473993,"name":"Adam O. Michel","orcid":null,"position":15,"is_corresponding":false},{"id":347724,"name":"Hiroshi Mukae","orcid":"0000-0002-1429-5706","position":16,"is_corresponding":false},{"id":225995,"name":"Elisa de Stanchina","orcid":"0000-0002-3873-315X","position":17,"is_corresponding":false},{"id":1555,"name":"Charles M. Rudin","orcid":"0000-0001-5204-3465","position":18,"is_corresponding":false},{"id":225638,"name":"Triparna Sen","orcid":"0000-0003-4673-7481","position":19,"is_corresponding":false},{"id":640074,"name":"Hirokazu Taniguchi","orcid":"0000-0003-2414-8344","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T00:21:25.223756Z","pmid":"35584676","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}