{"doi":"10.1016/j.celrep.2022.110812","title":"LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants","abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 (COVID-19) when administered early. However, SARS-CoV-2 variants of concern (VOCs) have negatively affected therapeutic use of some authorized mAbs. Using a high-throughput B cell screening pipeline, we isolated LY-CoV1404 (bebtelovimab), a highly potent SARS-CoV-2 spike glycoprotein receptor binding domain (RBD)-specific antibody. LY-CoV1404 potently neutralizes authentic SARS-CoV-2, B.1.1.7, B.1.351, and B.1.617.2. In pseudovirus neutralization studies, LY-CoV1404 potently neutralizes variants, including B.1.1.7, B.1.351, B.1.617.2, B.1.427/B.1.429, P.1, B.1.526, B.1.1.529, and the BA.2 subvariant. Structural analysis reveals that the contact residues of the LY-CoV1404 epitope are highly conserved, except for N439 and N501. The binding and neutralizing activity of LY-CoV1404 is unaffected by the most common mutations at these positions (N439K and N501Y). The broad and potent neutralization activity and the relatively conserved epitope suggest that LY-CoV1404 has the potential to be an effective therapeutic agent to treat all known variants.","journal":"Cell Reports","year":2022,"id":231765,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":464,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":617192,"name":"Stefanie Žentelis","orcid":null,"position":1,"is_corresponding":false},{"id":105588,"name":"Lingshu Wang","orcid":"0000-0002-8404-4910","position":2,"is_corresponding":false},{"id":617190,"name":"Denisa Foster","orcid":null,"position":3,"is_corresponding":false},{"id":810977,"name":"Peter Vaillancourt","orcid":null,"position":4,"is_corresponding":false},{"id":840744,"name":"Matthew Wiggin","orcid":null,"position":5,"is_corresponding":false},{"id":839400,"name":"Erica Lovett","orcid":"0000-0002-7572-7410","position":6,"is_corresponding":false},{"id":839401,"name":"Robin van der Lee","orcid":"0000-0001-7391-9438","position":7,"is_corresponding":false},{"id":615974,"name":"J. 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