{"doi":"10.1016/j.celrep.2022.110729","title":"Structural and functional impact by SARS-CoV-2 Omicron spike mutations","abstract":"The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bearing an unusually high number of mutations, has become a dominant strain in many countries within several weeks. We report here structural, functional, and antigenic properties of its full-length spike (S) protein with a native sequence in comparison with those of previously prevalent variants. Omicron S requires a substantially higher level of host receptor ACE2 for efficient membrane fusion than other variants, possibly explaining its unexpected cellular tropism. Mutations not only remodel the antigenic structure of the N-terminal domain of the S protein but also alter the surface of the receptor-binding domain in a way not seen in other variants, consistent with its remarkable resistance to neutralizing antibodies. These results suggest that Omicron S has acquired an extraordinary ability to evade host immunity by excessive mutations, which also compromise its fusogenic capability.","journal":"Cell Reports","year":2022,"id":232731,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":169,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9638,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106133,"name":"Yongfei Cai","orcid":"0000-0002-3628-3802","position":1,"is_corresponding":false},{"id":245206,"name":"Christy L. Lavine","orcid":"0000-0001-6135-0547","position":2,"is_corresponding":false},{"id":106136,"name":"Hanqin Peng","orcid":"0000-0002-5357-8215","position":3,"is_corresponding":false},{"id":616100,"name":"Haisun Zhu","orcid":"0000-0001-8395-9409","position":4,"is_corresponding":false},{"id":618886,"name":"Krishna Anand","orcid":"0000-0002-3824-3951","position":5,"is_corresponding":false},{"id":245202,"name":"Pei Tong","orcid":"0000-0003-4301-6857","position":6,"is_corresponding":false},{"id":245203,"name":"Avneesh Gautam","orcid":"0000-0003-1745-5530","position":7,"is_corresponding":false},{"id":271125,"name":"Megan L. Mayer","orcid":"0000-0001-9738-786X","position":8,"is_corresponding":false},{"id":106140,"name":"Sophia Rits‐Volloch","orcid":"0000-0003-2910-1422","position":9,"is_corresponding":false},{"id":516513,"name":"Shaowei Wang","orcid":"0000-0002-1267-9554","position":10,"is_corresponding":false},{"id":311610,"name":"Piotr Sliz","orcid":"0000-0002-6522-0835","position":11,"is_corresponding":false},{"id":106756,"name":"Duane R. Wesemann","orcid":"0000-0002-6690-944X","position":12,"is_corresponding":false},{"id":616101,"name":"Wei Yang","orcid":"0000-0002-7634-6601","position":13,"is_corresponding":false},{"id":16991,"name":"Michael S. Seaman","orcid":"0000-0001-6444-3562","position":14,"is_corresponding":false},{"id":7770,"name":"Jianming Lü","orcid":"0000-0002-3794-641X","position":15,"is_corresponding":false},{"id":106135,"name":"Tianshu Xiao","orcid":"0000-0003-1287-1228","position":16,"is_corresponding":false},{"id":106141,"name":"Bing Chen","orcid":"0000-0002-8625-1657","position":17,"is_corresponding":false},{"id":106134,"name":"Jun Zhang","orcid":"0000-0002-1289-0624","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-19T00:21:18.683916Z","pmid":"35452593","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}