{"doi":"10.1016/j.celrep.2022.110680","title":"mRNA vaccination in octogenarians 15 and 20 months after recovery from COVID-19 elicits robust immune and antibody responses that include Omicron","abstract":"Knowledge about the impact of prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the elderly on mRNA vaccination response is needed to appropriately address the demand for additional vaccinations in this vulnerable population. Here, we show that octogenarians, a high-risk population, mount a sustained SARS-CoV-2 spike-specific immunoglobulin G (IgG) antibody response for 15 months following infection. This response boosts antibody levels 35-fold upon receiving a single dose of BNT162b2 mRNA vaccine 15 months after recovery from coronavirus disease 2019 (COVID-19). In contrast, antibody responses in naive individuals boost only 6-fold after a second vaccine. Spike-specific angiotensin-converting enzyme 2 (ACE2) antibody binding responses in the previously infected octogenarians following two vaccine doses exceed those found in a naive cohort after two doses. RNA sequencing (RNA-seq) demonstrates activation of interferon-induced genetic programs, which persist only in the previously infected. A preferential increase of specific immunoglobulin G heavy chain variable (IGHV) clonal transcripts that are the basis of neutralizing antibodies is observed only in the previously infected nuns.","journal":"Cell Reports","year":2022,"id":246112,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9621,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576165,"name":"Ludwig Knabl","orcid":"0000-0001-8280-8991","position":1,"is_corresponding":false},{"id":266883,"name":"Juan I. Moliva","orcid":"0000-0001-9881-7112","position":2,"is_corresponding":false},{"id":266887,"name":"Anne P. Werner","orcid":"0000-0003-2322-6830","position":4,"is_corresponding":false},{"id":105570,"name":"Seyhan Boyoglu-Barnum","orcid":null,"position":5,"is_corresponding":false},{"id":806302,"name":"Sebastian Kapferer","orcid":null,"position":6,"is_corresponding":false},{"id":806303,"name":"Birgit Pateter","orcid":null,"position":7,"is_corresponding":false},{"id":234133,"name":"Mary Walter","orcid":null,"position":8,"is_corresponding":false},{"id":266889,"name":"Nancy J. Sullivan","orcid":"0000-0002-2159-2039","position":9,"is_corresponding":false},{"id":576168,"name":"Priscilla A. Furth","orcid":"0000-0003-3883-0715","position":10,"is_corresponding":false},{"id":14888,"name":"Lothar Hennighausen","orcid":"0000-0001-8319-9841","position":11,"is_corresponding":false},{"id":279569,"name":"Hye‐Kyung Lee","orcid":"0000-0002-7785-5942","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T00:23:43.438539Z","pmid":"35395191","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}