{"doi":"10.1016/j.celrep.2022.110679","title":"Escargot controls somatic stem cell maintenance through the attenuation of the insulin receptor pathway in Drosophila","abstract":"Adult stem cells coordinate intrinsic and extrinsic, local and systemic, cues to maintain the proper balance between self-renewal and differentiation. However, the precise mechanisms stem cells use to integrate these signals remain elusive. Here, we show that Escargot (Esg), a member of the Snail family of transcription factors, regulates the maintenance of somatic cyst stem cells (CySCs) in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor (InR) pathway. Esg positively regulates the expression of an antagonist of insulin signaling, ImpL2, while also attenuating the expression of InR. Furthermore, Esg-mediated repression of the InR pathway is required to suppress CySC loss in response to starvation. Given the conservation of Snail-family transcription factors, characterizing the mechanisms by which Esg regulates cell-fate decisions during homeostasis and a decline in nutrient availability is likely to provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms.","journal":"Cell Reports","year":2022,"id":258573,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":910134,"name":"Brian J. Stack","orcid":"0000-0002-8159-9777","position":1,"is_corresponding":false},{"id":910691,"name":"Alexander M. Tang","orcid":null,"position":2,"is_corresponding":false},{"id":910692,"name":"Justin Voog","orcid":null,"position":3,"is_corresponding":false},{"id":910135,"name":"Sharsti Sandall","orcid":"0000-0003-2519-4131","position":4,"is_corresponding":false},{"id":409329,"name":"Tony D. Southall","orcid":"0000-0002-8645-4198","position":5,"is_corresponding":false},{"id":36523,"name":"Andrea H. Brand","orcid":"0000-0002-2089-6954","position":6,"is_corresponding":false},{"id":283994,"name":"D. Leanne Jones","orcid":"0000-0001-5721-6310","position":7,"is_corresponding":false},{"id":283993,"name":"Rafael Sênos Demarco","orcid":"0000-0003-0009-4281","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T00:25:43.037820Z","pmid":"35443165","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}