{"doi":"10.1016/j.celrep.2022.110637","title":"Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma","abstract":"ARID2 is the most recurrently mutated SWI/SNF complex member in melanoma; however, its tumor-suppressive mechanisms in the context of the chromatin landscape remain to be elucidated. Here, we model ARID2 deficiency in melanoma cells, which results in defective PBAF complex assembly with a concomitant genomic redistribution of the BAF complex. Upon ARID2 depletion, a subset of PBAF and shared BAF-PBAF-occupied regions displays diminished chromatin accessibility and associated gene expression, while BAF-occupied enhancers gain chromatin accessibility and expression of genes linked to the process of invasion. As a function of altered accessibility, the genomic occupancy of melanoma-relevant transcription factors is affected and significantly correlates with the observed transcriptional changes. We further demonstrate that ARID2-deficient cells acquire the ability to colonize distal organs in multiple animal models. Taken together, our results reveal a role for ARID2 in mediating BAF and PBAF subcomplex chromatin dynamics with consequences for melanoma metastasis.","journal":"Cell Reports","year":2022,"id":240920,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":687492,"name":"Christie B. Nguyen","orcid":null,"position":1,"is_corresponding":false},{"id":869060,"name":"Elena Grossi","orcid":"0000-0003-3938-5000","position":2,"is_corresponding":false},{"id":813467,"name":"Dan Filipescu","orcid":"0000-0001-6381-2557","position":3,"is_corresponding":false},{"id":303985,"name":"Aktan Alpsoy","orcid":"0000-0002-8940-8277","position":4,"is_corresponding":false},{"id":303987,"name":"Alisha Dhiman","orcid":"0000-0002-4395-9292","position":5,"is_corresponding":false},{"id":712864,"name":"Dan Sun","orcid":"0000-0001-6464-5973","position":6,"is_corresponding":false},{"id":650271,"name":"Sonali Narang","orcid":"0000-0002-1138-0067","position":7,"is_corresponding":false},{"id":228659,"name":"Jochen Imig","orcid":"0000-0003-0385-1081","position":8,"is_corresponding":false},{"id":31291,"name":"Tiphaine Martin","orcid":"0000-0001-9990-1455","position":9,"is_corresponding":false},{"id":4789,"name":"Ramon Parsons","orcid":"0000-0002-6656-3514","position":10,"is_corresponding":false},{"id":109597,"name":"Iannis Aifantis","orcid":"0000-0001-6857-1035","position":11,"is_corresponding":false},{"id":69214,"name":"Aristotelis Tsirigos","orcid":"0000-0002-7512-8477","position":12,"is_corresponding":false},{"id":105283,"name":"Julio A. Aguirre‐Ghiso","orcid":"0000-0002-6694-6507","position":13,"is_corresponding":false},{"id":303990,"name":"Emily C. Dykhuizen","orcid":"0000-0003-3072-1469","position":14,"is_corresponding":false},{"id":329959,"name":"Dan Hasson","orcid":"0000-0001-7943-1636","position":15,"is_corresponding":false},{"id":329958,"name":"Emily Bernstein","orcid":"0000-0001-6533-8326","position":16,"is_corresponding":false},{"id":813468,"name":"Saul Carcamo","orcid":"0000-0002-1510-1045","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-19T00:22:51.435773Z","pmid":"35385731","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}