{"doi":"10.1016/j.celrep.2022.110388","title":"Balanced T and B cell responses are required for immune protection against Powassan virus in virus-like particle vaccination","abstract":"Powassan virus (POWV) is a tick-borne pathogen for which humans are an incidental host. POWV infection can be fatal or result in long-term neurological sequelae; however, there are no approved vaccinations for POWV. Integral to efficacious vaccine development is the identification of correlates of protection, which we accomplished in this study by utilizing a murine model of POWV infection. Using POWV lethal and sub-lethal challenge models, we show that (1) robust B and T cell responses are necessary for immune protection, (2) POWV lethality can be attributed to both viral- and host-mediated drivers of disease, and (3) knowledge of the immune correlates of protection against POWV can be applied in a virus-like particle (VLP)-based vaccination approach that provides protection from lethal POWV challenge. Identification of these immune protection factors is significant as it will aid in the rational design of POWV vaccines.","journal":"Cell Reports","year":2022,"id":254129,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409037,"name":"Mariah Hassert","orcid":"0000-0002-2141-3344","position":1,"is_corresponding":false},{"id":409041,"name":"Elizabeth Geerling","orcid":"0000-0002-5104-499X","position":2,"is_corresponding":false},{"id":901275,"name":"Colleen Wagner","orcid":null,"position":3,"is_corresponding":false},{"id":282037,"name":"James D. Brien","orcid":"0000-0002-1670-8041","position":4,"is_corresponding":false},{"id":301010,"name":"Gregory D. Ebel","orcid":"0000-0002-4458-9959","position":5,"is_corresponding":false},{"id":463506,"name":"Alec J. Hirsch","orcid":"0000-0002-8613-0740","position":6,"is_corresponding":false},{"id":482414,"name":"Cody N. German","orcid":"0000-0002-8035-7274","position":7,"is_corresponding":false},{"id":463500,"name":"Jessica L. Smith","orcid":"0000-0002-8153-2484","position":8,"is_corresponding":false},{"id":290891,"name":"Amelia K. Pinto","orcid":"0000-0002-7147-3978","position":9,"is_corresponding":false},{"id":409039,"name":"E. Taylor Stone","orcid":"0000-0001-6742-1270","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T00:25:03.918844Z","pmid":"35172138","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}