{"doi":"10.1016/j.celrep.2021.110079","title":"CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia","abstract":"CD19-CAR T cells post-infusion in ALL patients. We report that CAR T cells undergo a rapid and broad erasure of repressive DNA methylation reprograms at effector-associated genes. The CAR T cell post-infusion changes are further characterized by repression of genes (e.g., TCF7 and LEF1) associated with memory potential and a DNA methylation signature (e.g., demethylation at CX3CR1, BATF, and TOX) demarcating a transition toward exhaustion-progenitor T cells. Thus, CD19-CAR T cells undergo exhaustion-associated DNA methylation programming, indicating that efforts to prevent this process may be an attractive approach to improve CAR T cell efficacy.","journal":"Cell Reports","year":2021,"id":149620,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":104,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":636381,"name":"Charmaine Brown","orcid":"0000-0001-5716-9550","position":1,"is_corresponding":false},{"id":302243,"name":"Mi Tian","orcid":"0000-0002-6446-1995","position":2,"is_corresponding":false},{"id":250676,"name":"Yiping Fan","orcid":"0000-0002-8430-4620","position":3,"is_corresponding":false},{"id":271009,"name":"Shanta Alli","orcid":"0000-0003-1692-1616","position":4,"is_corresponding":false},{"id":250673,"name":"Shannon K. Boi","orcid":"0000-0001-9479-5665","position":5,"is_corresponding":false},{"id":636382,"name":"Giovanni Galletti","orcid":"0000-0001-6613-2354","position":6,"is_corresponding":false},{"id":318401,"name":"Enrico Lugli","orcid":"0000-0002-1964-7678","position":7,"is_corresponding":false},{"id":461630,"name":"Deanna Langfitt","orcid":"0000-0003-0941-5360","position":8,"is_corresponding":false},{"id":636383,"name":"Jean‐Yves Métais","orcid":"0000-0002-9627-3104","position":9,"is_corresponding":false},{"id":486484,"name":"Timothy Lockey","orcid":"0000-0002-9231-6840","position":10,"is_corresponding":false},{"id":486485,"name":"Michael M. Meagher","orcid":"0000-0003-0300-3349","position":11,"is_corresponding":false},{"id":415747,"name":"Brandon M. Triplett","orcid":"0000-0001-8220-9980","position":12,"is_corresponding":false},{"id":487064,"name":"Aimee C. Talleur","orcid":"0000-0002-6558-6706","position":13,"is_corresponding":false},{"id":3653,"name":"Stephen Gottschalk","orcid":"0000-0003-3991-7468","position":14,"is_corresponding":false},{"id":250684,"name":"Ben Youngblood","orcid":"0000-0002-1261-9957","position":15,"is_corresponding":false},{"id":271005,"name":"Caitlin C. Zebley","orcid":"0000-0002-8419-4660","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-18T23:42:56.251607Z","pmid":"34852226","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}