{"doi":"10.1016/j.celrep.2021.110071","title":"Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex","abstract":"T cells recognizing the ubiquitous pathogens influenza and cytomegalovirus. Our results reveal that virus specificity determines overall magnitude, tissue distribution, differentiation, and clonal repertoire of virus-specific T cells. Age and sex influence T cell differentiation and dissemination in tissues, while T cell tissue residence and functionality are highly correlated with the site. Together, our results demonstrate how the covariates of virus, tissue, age, and sex impact the anti-viral immune response, which is important for targeting, monitoring, and predicting immune responses to existing and emerging viruses.","journal":"Cell Reports","year":2021,"id":154553,"datarank":1.5916051658666555,"base_score":4.174387269895637,"endowment":4.174387269895637,"self_citation_contribution":0.6261580904843456,"citation_network_contribution":0.9654470753823099,"self_endowment_contribution":0.6261580904843456,"citer_contribution":0.9654470753823099,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":48,"citers_with_citation_signal":39,"citers_with_endowment":39,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":655028,"name":"Eve Byington","orcid":"0000-0001-5624-9073","position":1,"is_corresponding":false},{"id":108193,"name":"Wenzhao Meng","orcid":"0000-0002-8040-7825","position":2,"is_corresponding":false},{"id":621509,"name":"Masaru Kubota","orcid":"0000-0002-4095-738X","position":3,"is_corresponding":false},{"id":229312,"name":"Rei Matsumoto","orcid":null,"position":4,"is_corresponding":false},{"id":103765,"name":"Alba Grifoni","orcid":"0000-0002-0369-1746","position":5,"is_corresponding":false},{"id":103766,"name":"Daniela Weiskopf","orcid":"0000-0003-2968-7371","position":6,"is_corresponding":false},{"id":225927,"name":"Pranay Dogra","orcid":"0000-0003-2031-9855","position":7,"is_corresponding":false},{"id":350514,"name":"Nora Lam","orcid":"0000-0002-8933-3121","position":8,"is_corresponding":false},{"id":225925,"name":"Peter A. Szabo","orcid":"0000-0003-1603-761X","position":9,"is_corresponding":false},{"id":621511,"name":"Basak B. Ural","orcid":"0000-0003-0671-2933","position":10,"is_corresponding":false},{"id":225926,"name":"Steven B. Wells","orcid":"0000-0001-5428-0683","position":11,"is_corresponding":false},{"id":108194,"name":"Aaron M. Rosenfeld","orcid":"0000-0002-2266-0355","position":12,"is_corresponding":false},{"id":356517,"name":"Maigan A. Brusko","orcid":"0000-0002-4331-2202","position":13,"is_corresponding":false},{"id":356521,"name":"Todd M. Brusko","orcid":"0000-0003-2878-9296","position":14,"is_corresponding":false},{"id":225921,"name":"Thomas J. Connors","orcid":"0000-0002-0199-7733","position":15,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":16,"is_corresponding":false},{"id":225061,"name":"Peter A. Sims","orcid":"0000-0002-3921-4837","position":17,"is_corresponding":false},{"id":244597,"name":"Eline T. Luning Prak","orcid":"0000-0002-9478-9211","position":18,"is_corresponding":false},{"id":23573,"name":"Yufeng Shen","orcid":"0000-0002-1299-5979","position":19,"is_corresponding":false},{"id":225941,"name":"Donna L. Färber","orcid":"0000-0001-8236-9183","position":20,"is_corresponding":false},{"id":229313,"name":"Maya M.L. Poon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:54.469024Z","pmid":"34852222","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}