{"doi":"10.1016/j.celrep.2021.109969","title":"MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response","abstract":"MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults.","journal":"Cell Reports","year":2021,"id":179885,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":248170,"name":"Hongya Zhu","orcid":null,"position":1,"is_corresponding":false},{"id":728207,"name":"Ciarán W.P. Daly","orcid":"0000-0002-8607-4056","position":2,"is_corresponding":false},{"id":655570,"name":"Luyen Tien Vu","orcid":"0000-0002-4953-6469","position":3,"is_corresponding":false},{"id":728208,"name":"Norah L. Smith","orcid":"0000-0002-7495-7660","position":4,"is_corresponding":false},{"id":472060,"name":"Ravi K. Patel","orcid":"0000-0001-5203-899X","position":5,"is_corresponding":false},{"id":246117,"name":"David J. Topham","orcid":"0000-0002-9435-8673","position":6,"is_corresponding":false},{"id":436587,"name":"Kristin Scheible","orcid":"0000-0002-7879-8222","position":7,"is_corresponding":false},{"id":324159,"name":"Kondwani Jambo","orcid":"0000-0002-3195-2210","position":8,"is_corresponding":false},{"id":558796,"name":"Minh T. N. Le","orcid":"0000-0002-6077-1566","position":9,"is_corresponding":false},{"id":728209,"name":"Brian D. Rudd","orcid":"0000-0002-9742-8358","position":10,"is_corresponding":false},{"id":353654,"name":"Andrew Grimson","orcid":"0000-0002-5794-6484","position":11,"is_corresponding":false},{"id":728206,"name":"Kristel Joy Yee Mon","orcid":"0000-0001-7355-4811","position":0,"is_corresponding":true}],"reference_count":100,"raw_metadata":null,"created_at":"2026-07-18T23:47:53.089578Z","pmid":"34758312","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}