{"doi":"10.1016/j.celrep.2021.109942","title":"Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation","abstract":"Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.","journal":"Cell Reports","year":2021,"id":181546,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459156,"name":"Chase E. Hawes","orcid":"0000-0002-5927-9793","position":1,"is_corresponding":false},{"id":558226,"name":"Yashavanth Shaan Lakshmanappa","orcid":null,"position":2,"is_corresponding":false},{"id":340725,"name":"Jamin W. Roh","orcid":null,"position":3,"is_corresponding":false},{"id":405166,"name":"Brian Schmidt","orcid":"0000-0002-3405-4862","position":4,"is_corresponding":false},{"id":557441,"name":"Joseph Dutra","orcid":"0000-0002-5553-5200","position":5,"is_corresponding":false},{"id":440056,"name":"William Louie","orcid":"0000-0003-1139-1476","position":6,"is_corresponding":false},{"id":4806,"name":"Hongwei Liu","orcid":"0000-0001-6471-131X","position":7,"is_corresponding":false},{"id":557443,"name":"Zhong-Min Ma","orcid":"0000-0003-3713-7337","position":8,"is_corresponding":false},{"id":407468,"name":"Jennifer Watanabe","orcid":"0000-0001-9408-3991","position":9,"is_corresponding":false},{"id":717435,"name":"Jodie L. Usachenko","orcid":null,"position":10,"is_corresponding":false},{"id":477728,"name":"Ramya Immareddy","orcid":"0000-0002-3612-1985","position":11,"is_corresponding":false},{"id":425694,"name":"Rebecca L. Sammak","orcid":"0000-0003-3271-0413","position":12,"is_corresponding":false},{"id":437605,"name":"Rachel E. Pollard","orcid":"0000-0003-2986-1827","position":13,"is_corresponding":false},{"id":515986,"name":"J. Rachel Reader","orcid":"0000-0003-3864-6731","position":14,"is_corresponding":false},{"id":557442,"name":"Katherine J. Olstad","orcid":"0000-0003-3894-0981","position":15,"is_corresponding":false},{"id":407475,"name":"Lark L. Coffey","orcid":"0000-0002-0718-5146","position":16,"is_corresponding":false},{"id":253822,"name":"Pamela A. Kozlowski","orcid":"0000-0001-9906-6234","position":17,"is_corresponding":false},{"id":413411,"name":"Dennis J. Hartigan-O’Connor","orcid":"0000-0003-4822-636X","position":18,"is_corresponding":false},{"id":104187,"name":"Michel C. Nussenzweig","orcid":"0000-0003-0592-8564","position":19,"is_corresponding":false},{"id":399793,"name":"Koen K. A. Van Rompay","orcid":"0000-0002-7375-1337","position":20,"is_corresponding":false},{"id":515987,"name":"John H. Morrison","orcid":"0000-0002-8292-0964","position":21,"is_corresponding":false},{"id":297247,"name":"Smita S. Iyer","orcid":"0000-0002-8918-7005","position":22,"is_corresponding":false},{"id":372011,"name":"Anil Verma","orcid":"0000-0002-0024-7826","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:48:05.146883Z","pmid":"34706272","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}