{"doi":"10.1016/j.celrep.2021.109865","title":"Mice hypomorphic for Pitx3 show robust entrainment of circadian behavioral and metabolic rhythms to scheduled feeding","abstract":"Pitx3ak mice lack a functioning retina and develop fewer than 10% of dopamine neurons in the substantia nigra. Del Río-Martín et al., 2019Del Río-Martín A. Pérez-Taboada I. Fernández-Pérez A. Moratalla R. de la Villa P. Vallejo M. Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure.Cell Rep. 2019; 29: 3678-3692.e4Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar reported that entrainment of circadian rhythms to daily light-dark (LD) cycles is absent in these mice, and that rhythms of locomotor activity, energy expenditure, and other metabolic variables are disrupted with food available ad libitum and fail to entrain to a daily feeding. The authors propose that retinal innervation of the suprachiasmatic nucleus is required for development of cyclic metabolic homeostasis, but methodological issues limit interpretation of the results. Using standardized feeding schedules and procedures for distinguishing free-running from entrained circadian rhythms, we confirm that behavioral and metabolic rhythms in Pitx3ak mice do not entrain to LD cycles, but we find no impairment in circadian organization of metabolism with food available ad libitum and no impairment in entrainment of metabolic or behavioral rhythms by daily feeding schedules. This Matters Arising paper is in response to Del Río-Martín et al., 2019Del Río-Martín A. Pérez-Taboada I. Fernández-Pérez A. Moratalla R. de la Villa P. Vallejo M. Hypomorphic Expression of Pitx3 Disrupts Circadian Clocks and Prevents Metabolic Entrainment of Energy Expenditure.Cell Rep. 2019; 29: 3678-3692.e4Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar, published in Cell Reports. See also the response by Fernández-Pérez et al., 2022Fernández-Pérez A. Sanz-Magro A. Moratalla R. Vallejo M. Restricting feeding to the dark phase fails to entrain circadian locomotor activity and energy expenditure oscillations in Pitx3-mutant Aphakia mice.Cell Rep. 2022; 38: 110241Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar, published in this issue.","journal":"Cell Reports","year":2022,"id":281922,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":958048,"name":"Brad Wanken","orcid":null,"position":1,"is_corresponding":false},{"id":957571,"name":"Marten P. Smidt","orcid":"0000-0002-8815-747X","position":2,"is_corresponding":false},{"id":957572,"name":"Ralph E. Mistlberger","orcid":"0000-0001-6642-2706","position":3,"is_corresponding":false},{"id":524262,"name":"Andrew D. Steele","orcid":"0000-0001-8777-4970","position":4,"is_corresponding":false},{"id":957570,"name":"Lori L. Scarpa","orcid":"0000-0002-4421-1948","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-19T00:29:15.734856Z","pmid":"35021098","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}