{"doi":"10.1016/j.celrep.2021.109807","title":"TIGER: The gene expression regulatory variation landscape of human pancreatic islets","abstract":"Genome-wide association studies (GWASs) identified hundreds of signals associated with type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have created the translational human pancreatic islet genotype tissue-expression resource (TIGER), aggregating >500 human islet genomic datasets from five cohorts in the Horizon 2020 consortium T2DSystems. We impute genotypes using four reference panels and meta-analyze cohorts to improve the coverage of expression quantitative trait loci (eQTL) and develop a method to combine allele-specific expression across samples (cASE). We identify >1 million islet eQTLs, 53 of which colocalize with T2D signals. Among them, a low-frequency allele that reduces T2D risk by half increases CCND2 expression. We identify eight cASE colocalizations, among which we found a T2D-associated SLC30A8 variant. We make all data available through the TIGER portal (http://tiger.bsc.es), which represents a comprehensive human islet genomic data resource to elucidate how genetic variation affects islet function and translates into therapeutic insight and precision medicine for T2D.","journal":"Cell Reports","year":2021,"id":149650,"datarank":2.2452214007963094,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"self_citation_contribution":0.6966586348712059,"citation_network_contribution":1.5485627659251033,"self_endowment_contribution":0.6966586348712059,"citer_contribution":1.5485627659251033,"corpus_percentile":90.49276707666125,"corpus_rank":1230,"citation_count":103,"citer_count":66,"citers_with_citation_signal":49,"citers_with_endowment":49,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.9427,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":636453,"name":"Anthony Piron","orcid":"0000-0002-7931-3784","position":1,"is_corresponding":false},{"id":499615,"name":"Ignasi Morán","orcid":"0000-0002-3307-7106","position":2,"is_corresponding":false},{"id":499619,"name":"Marta Guindo-Martínez","orcid":"0000-0002-8099-9170","position":3,"is_corresponding":false},{"id":556042,"name":"Sílvia Bonàs‐Guarch","orcid":"0000-0002-2085-7488","position":4,"is_corresponding":false},{"id":636454,"name":"Goutham Atla","orcid":"0000-0002-4221-6251","position":5,"is_corresponding":false},{"id":246536,"name":"Irene Miguel-Escalada","orcid":"0000-0003-3461-6404","position":6,"is_corresponding":false},{"id":13987,"name":"Romina Royo","orcid":"0000-0003-3493-0874","position":7,"is_corresponding":false},{"id":13943,"name":"Montserrat Puiggròs","orcid":"0000-0001-5034-7924","position":8,"is_corresponding":false},{"id":637427,"name":"Xavier Garcia-Hurtado","orcid":null,"position":9,"is_corresponding":false},{"id":636455,"name":"Mara Suleiman","orcid":"0000-0002-2478-8782","position":10,"is_corresponding":false},{"id":262815,"name":"Lorella Marselli","orcid":"0000-0002-6698-2962","position":11,"is_corresponding":false},{"id":636456,"name":"Jonathan L.S. 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