{"doi":"10.1016/j.celrep.2021.109591","title":"B cells promote CD8 T cell primary and memory responses to subunit vaccines","abstract":"The relationship between B cells and CD4 T cells has been carefully studied, revealing a collaborative effort in which B cells promote the activation, differentiation, and expansion of CD4 T cells while the so-called \"helper\" cells provide signals to B cells, influencing their class switching and fate. Interactions between B cells and CD8 T cells are not as well studied, although CD8 T cells exhibit an accelerated contraction after certain infections in B-cell-deficient mice. Here, we find that B cells significantly enhance primary CD8 T cell responses after vaccination. Moreover, memory CD8 numbers and function are impaired in B-cell-deficient animals, leading to increased susceptibility to bacterial challenge. We also show that interleukin-27 production by B cells contributes to their impact on primary, but not memory, CD8 responses. Better understanding of the interactions between CD8 T cells and B cells may aid in the design of more effective future vaccine strategies.","journal":"Cell Reports","year":2021,"id":157261,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":663663,"name":"Eric Cross","orcid":"0000-0003-0482-5969","position":1,"is_corresponding":false},{"id":663664,"name":"Scott B. Thompson","orcid":"0000-0001-8270-1983","position":2,"is_corresponding":false},{"id":664277,"name":"Benjamin Willett","orcid":null,"position":3,"is_corresponding":false},{"id":530708,"name":"Daniel L. Aldridge","orcid":"0000-0003-2224-5159","position":4,"is_corresponding":false},{"id":664278,"name":"Alayna K. Caffrey-Carr","orcid":null,"position":5,"is_corresponding":false},{"id":379113,"name":"Zhenming Xu","orcid":"0000-0002-5822-0570","position":6,"is_corresponding":false},{"id":305888,"name":"Christopher A. Hunter","orcid":"0000-0003-3092-1428","position":7,"is_corresponding":false},{"id":411836,"name":"Andrew Getahun","orcid":"0000-0002-5663-6812","position":8,"is_corresponding":false},{"id":351178,"name":"Ross M. Kedl","orcid":"0000-0002-9065-7895","position":9,"is_corresponding":false},{"id":575818,"name":"Jared Klarquist","orcid":"0000-0002-4072-3962","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-18T23:44:17.471040Z","pmid":"34433030","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}