{"doi":"10.1016/j.celrep.2021.109553","title":"Coordination of tumor growth and host wasting by tumor-derived Upd3","abstract":"yki-induced gut tumors in Drosophila are associated with host wasting, including muscle dysfunction, lipid loss, and hyperglycemia, a condition reminiscent of human cancer cachexia. We previously used this model to identify tumor-derived ligands that contribute to host wasting. To identify additional molecular networks involved in host-tumor interactions, we develop PathON, a web-based tool analyzing the major signaling pathways in Drosophila, and uncover the Upd3/Jak/Stat axis as an important modulator. We find that yki-gut tumors secrete Upd3 to promote self-overproliferation and enhance Jak/Stat signaling in host organs to cause wasting, including muscle dysfunction, lipid loss, and hyperglycemia. We further reveal that Upd3/Jak/Stat signaling in the host organs directly triggers the expression of ImpL2, an antagonistic binding protein for insulin-like peptides, to impair insulin signaling and energy balance. Altogether, our results demonstrate that yki-gut tumors produce a Jak/Stat pathway ligand, Upd3, that regulates both self-growth and host wasting.","journal":"Cell Reports","year":2021,"id":149675,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":103,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":637441,"name":"Xiaoxiang Xiang","orcid":null,"position":1,"is_corresponding":false},{"id":259031,"name":"Yanhui Hu","orcid":"0000-0003-1494-1402","position":2,"is_corresponding":false},{"id":637442,"name":"Gen Xiao","orcid":null,"position":3,"is_corresponding":false},{"id":636518,"name":"Yuchen Chen","orcid":"0000-0001-8558-3062","position":4,"is_corresponding":false},{"id":330815,"name":"Richard Binari","orcid":"0000-0001-6155-9607","position":5,"is_corresponding":false},{"id":259036,"name":"Aram Comjean","orcid":"0000-0003-4125-0703","position":6,"is_corresponding":false},{"id":62240,"name":"Jiaying Li","orcid":"0000-0001-7508-1579","position":7,"is_corresponding":false},{"id":637443,"name":"Elisabeth Rushworth","orcid":null,"position":8,"is_corresponding":false},{"id":636519,"name":"Zhenming Fu","orcid":"0000-0003-2416-9591","position":9,"is_corresponding":false},{"id":259045,"name":"Stephanie E. Mohr","orcid":"0000-0001-9639-7708","position":10,"is_corresponding":false},{"id":14957,"name":"Norbert Perrimon","orcid":"0000-0001-7542-472X","position":11,"is_corresponding":false},{"id":636520,"name":"Wei Song","orcid":"0000-0002-7007-5281","position":12,"is_corresponding":false},{"id":637440,"name":"Guangming Ding","orcid":null,"position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T23:42:56.251607Z","pmid":"34407411","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}