{"doi":"10.1016/j.celrep.2021.109509","title":"3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus","abstract":"The brain's ability to process complex information relies on the constant supply of energy through aerobic respiration by mitochondria. Neurons contain three anatomically distinct compartments-the soma, dendrites, and projecting axons-which have different energetic and biochemical requirements, as well as different mitochondrial morphologies in cultured systems. In this study, we apply quantitative three-dimensional electron microscopy to map mitochondrial network morphology and complexity in the mouse brain. We examine somatic, dendritic, and axonal mitochondria in the dentate gyrus and cornu ammonis 1 (CA1) of the mouse hippocampus, two subregions with distinct principal cell types and functions. We also establish compartment-specific differences in mitochondrial morphology across these cell types between young and old mice, highlighting differences in age-related morphological recalibrations. Overall, these data define the nature of the neuronal mitochondrial network in the mouse hippocampus, providing a foundation to examine the role of mitochondrial morpho-function in the aging brain.","journal":"Cell Reports","year":2021,"id":147813,"datarank":0.7475409932562506,"base_score":4.983606621708336,"endowment":4.983606621708336,"self_citation_contribution":0.7475409932562506,"citation_network_contribution":0.0,"self_endowment_contribution":0.7475409932562506,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":145,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9208,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":384537,"name":"Clay Lacefield","orcid":null,"position":1,"is_corresponding":false},{"id":383306,"name":"Tracey Davey","orcid":"0000-0001-9409-7410","position":2,"is_corresponding":false},{"id":628675,"name":"Kathryn White","orcid":"0000-0003-2163-3547","position":3,"is_corresponding":false},{"id":628676,"name":"Ross Laws","orcid":"0000-0003-3241-2344","position":4,"is_corresponding":false},{"id":628677,"name":"Stylianos Kosmidis","orcid":"0000-0002-3534-5637","position":5,"is_corresponding":false},{"id":628678,"name":"Amy K. Reeve","orcid":"0000-0002-4474-2204","position":6,"is_corresponding":false},{"id":429868,"name":"Eric R. Kandel","orcid":"0000-0001-7851-6902","position":7,"is_corresponding":false},{"id":64646,"name":"Amy E. Vincent","orcid":"0000-0002-0360-6644","position":8,"is_corresponding":false},{"id":291014,"name":"Martin Picard","orcid":"0000-0003-2835-0478","position":9,"is_corresponding":false},{"id":628674,"name":"Julie Faitg","orcid":"0000-0003-0910-2217","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:42:35.448762Z","pmid":"34380033","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}