{"doi":"10.1016/j.celrep.2021.109502","title":"An mPOA-ARCAgRP pathway modulates cold-evoked eating behavior","abstract":null,"journal":"Cell Reports","year":2021,"id":592590,"datarank":1.3669396025612182,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.7926433930878537,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.7926433930878537,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":39,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1516452,"name":"Yu Lin Tan","orcid":null,"position":1,"is_corresponding":false},{"id":121175,"name":"Xiaohua Wu","orcid":null,"position":2,"is_corresponding":false},{"id":1489555,"name":"Jingjie Wang","orcid":"0000-0003-3700-3013","position":3,"is_corresponding":false},{"id":1482312,"name":"Jingjing Sun","orcid":"0000-0001-7331-0163","position":4,"is_corresponding":false},{"id":1168531,"name":"Anqi Liu","orcid":"0009-0000-1913-4680","position":5,"is_corresponding":false},{"id":431674,"name":"Linhua Gan","orcid":"0000-0003-4140-3845","position":6,"is_corresponding":false},{"id":288253,"name":"Bo Shen","orcid":"0000-0002-5237-6144","position":7,"is_corresponding":false},{"id":335986,"name":"Xiaocui Zhang","orcid":null,"position":8,"is_corresponding":false},{"id":550327,"name":"Yu Fu","orcid":"0000-0003-2520-2189","position":9,"is_corresponding":false},{"id":36641,"name":"Ju Huang","orcid":null,"position":10,"is_corresponding":false},{"id":280572,"name":"Shuo Yang","orcid":"0000-0001-9085-5085","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"An mPOA-ARCAgRP pathway modulates cold-evoked eating behavior","abstract":"Enhanced appetite occurs as a means of behavioral thermoregulation at low temperature. Neural circuitry mediating this crosstalk between behavioral thermoregulation and energy homeostasis remains to be elucidated. We find that the hypothalamic orexigenic agouti-related neuropeptide (AgRP) neurons in the arcuate nucleus (ARC) are profoundly activated by cold exposure. The calcium signals in ARCAgRP neurons display an immediate-response pattern in response to cold stimulation. Cold-responsive neurons in the medial preoptic area (mPOA) make excitatory synapses onto ARCAgRP neurons. Inhibition of either ARCAgRP neurons or ARC-projecting mPOA neurons attenuates cold-evoked feeding, while activation of the mPOA-to-ARC projection increases food intake. These findings reveal an mPOA-ARCAgRP neural pathway that modulates cold-evoked feeding behavior.","is_dataset_classified":null,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34380037","pmcid":null,"openalex_id":"https://openalex.org/W3187695507","authors":[],"funders":[],"total_grants":0,"fwci":2.1561,"citation_percentile":0.88054139,"influential_citations":0,"citation_trend":[{"year":2022,"count":8},{"year":2023,"count":9},{"year":2024,"count":7},{"year":2025,"count":16},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S221112472100930X/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S221112472100930X/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S221112472100930X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S221112472100930X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2021.109502","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34380037","host_type":"repository"},{"url":"https://doaj.org/article/ca312801c59345bfad8cb94b1f2d6e42","host_type":"repository"}],"fields_of_study":["Regulation of Appetite and Obesity","Ion Channels and Receptors","Biochemical Analysis and Sensing Techniques","Agouti-Related Protein","Animals","Arcuate Nucleus of Hypothalamus","Cold Temperature","Feeding Behavior","Mice, Inbred C57BL","Neural Pathways","Neurons","Preoptic Area","Synapses","Mice"],"mesh_terms":["Animals","Arcuate Nucleus of Hypothalamus","Cold Temperature","Feeding Behavior","Mice, Inbred C57BL","Neural Pathways","Neurons","Preoptic Area","Synapses","Mice","Agouti-Related Protein"],"keywords":["Psychology","Chemistry","Neuroscience","Biology","Poa","Thermoregulation","Appetite","Hyperphagia","Arc","Energy Homeostasis","Agrp Neurons","Medial Preoptic Area","Eating Regulation","Cold-evoked Feeding"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T14:23:20.268734Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}