{"doi":"10.1016/j.celrep.2021.109376","title":"Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism","abstract":"eIF5-mimic protein (5MP) is a translational regulatory protein that binds the small ribosomal subunit and modulates its activity. 5MP is proposed to reprogram non-AUG translation rates for oncogenes in cancer, but its role in controlling non-AUG initiated synthesis of deleterious repeat-peptide products, such as FMRpolyG observed in fragile-X-associated tremor ataxia syndrome (FXTAS), is unknown. Here, we show that 5MP can suppress both general and repeat-associated non-AUG (RAN) translation by a common mechanism in a manner dependent on its interaction with eIF3. Essentially, 5MP displaces eIF5 through the eIF3c subunit within the preinitiation complex (PIC), thereby increasing the accuracy of initiation. In Drosophila, 5MP/Kra represses neuronal toxicity and enhances the lifespan in an FXTAS disease model. These results implicate 5MP in protecting cells from unwanted byproducts of non-AUG translation in neurodegeneration.","journal":"Cell Reports","year":2021,"id":165833,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":689857,"name":"M. Rebecca Glineburg","orcid":"0000-0002-8615-2894","position":1,"is_corresponding":false},{"id":138073,"name":"Chelsea Moore","orcid":null,"position":2,"is_corresponding":false},{"id":689858,"name":"Naoki Tani","orcid":"0000-0003-2169-135X","position":3,"is_corresponding":false},{"id":461594,"name":"Rahul Jaiswal","orcid":"0000-0002-4379-3798","position":4,"is_corresponding":false},{"id":689859,"name":"Ye Zou","orcid":"0000-0002-3145-9661","position":5,"is_corresponding":false},{"id":138080,"name":"Eric Aube","orcid":null,"position":6,"is_corresponding":false},{"id":138076,"name":"Sarah Gillaspie","orcid":null,"position":7,"is_corresponding":false},{"id":370542,"name":"Mackenzie Thornton","orcid":null,"position":8,"is_corresponding":false},{"id":370544,"name":"Ariana Cecil","orcid":null,"position":9,"is_corresponding":false},{"id":369730,"name":"Madelyn Hilgers","orcid":"0000-0001-5695-1508","position":10,"is_corresponding":false},{"id":690342,"name":"Azuma Takasu","orcid":null,"position":11,"is_corresponding":false},{"id":370545,"name":"Izumi Asano","orcid":null,"position":12,"is_corresponding":false},{"id":690343,"name":"Masayo Asano","orcid":null,"position":13,"is_corresponding":false},{"id":461600,"name":"Carlos Escalante","orcid":"0000-0001-5648-3361","position":14,"is_corresponding":false},{"id":564772,"name":"Akira Nakamura","orcid":"0000-0001-6506-9146","position":15,"is_corresponding":false},{"id":395497,"name":"Peter K. Todd","orcid":"0000-0003-4781-6376","position":16,"is_corresponding":false},{"id":369734,"name":"Katsura Asano","orcid":"0000-0002-8636-0263","position":17,"is_corresponding":false},{"id":369733,"name":"Chingakham Ranjit Singh","orcid":"0000-0003-2840-3066","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-18T23:45:40.838485Z","pmid":"34260931","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}