{"doi":"10.1016/j.celrep.2021.109197","title":"SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression","abstract":") to a growth defect. ORF7a is implicated in immune modulation, and we show that the C-terminal truncation negates anti-immune activities of the protein, which results in elevated type I interferon response to the viral infection. Collectively, this work indicates that ORF7a mutations occur frequently, and that these changes affect viral mechanisms responsible for suppressing the immune response.","journal":"Cell Reports","year":2021,"id":151164,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226295,"name":"Anna Nemudraia","orcid":"0000-0002-4190-6306","position":1,"is_corresponding":false},{"id":226296,"name":"Tanner Wiegand","orcid":"0000-0002-0528-268X","position":2,"is_corresponding":false},{"id":642492,"name":"Joseph Nichols","orcid":"0000-0002-7142-1457","position":3,"is_corresponding":false},{"id":527323,"name":"Deann T. Snyder","orcid":"0000-0003-3087-7260","position":4,"is_corresponding":false},{"id":527322,"name":"Jodi F. Hedges","orcid":"0000-0002-7461-3972","position":5,"is_corresponding":false},{"id":229394,"name":"Calvin Cicha","orcid":null,"position":6,"is_corresponding":false},{"id":333854,"name":"Helen Lee","orcid":"0000-0002-9999-6842","position":7,"is_corresponding":false},{"id":226299,"name":"Karl K. Vanderwood","orcid":"0009-0002-9994-2374","position":8,"is_corresponding":false},{"id":412132,"name":"Diane Bimczok","orcid":"0000-0002-8817-7243","position":9,"is_corresponding":false},{"id":527324,"name":"Mark A. Jutila","orcid":"0000-0002-4120-1349","position":10,"is_corresponding":false},{"id":226301,"name":"Blake Wiedenheft","orcid":"0000-0001-9297-5304","position":11,"is_corresponding":false},{"id":226294,"name":"Artem Nemudryi","orcid":"0000-0003-0121-1363","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-18T23:43:11.293086Z","pmid":"34043946","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}