{"doi":"10.1016/j.celrep.2021.109009","title":"Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity","abstract":"Cancer cells function as primary architects of the tumor microenvironment. However, the molecular features of cancer cells that govern stromal cell phenotypes remain unclear. Here, we show that cancer-associated fibroblast (CAF) heterogeneity is driven by lung adenocarcinoma (LUAD) cells at either end of the epithelial-to-mesenchymal transition (EMT) spectrum. LUAD cells that have high expression of the EMT-activating transcription factor ZEB1 reprogram CAFs through a ZEB1-dependent secretory program and direct CAFs to the tips of invasive projections through a ZEB1-driven CAF repulsion process. The EMT, in turn, sensitizes LUAD cells to pro-metastatic signals from CAFs. Thus, CAFs respond to contextual cues from LUAD cells to promote metastasis.","journal":"Cell Reports","year":2021,"id":167261,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311136,"name":"Priyam Banerjee","orcid":"0000-0001-9398-9345","position":1,"is_corresponding":false},{"id":565665,"name":"Yichi Niu","orcid":"0000-0002-4376-7792","position":2,"is_corresponding":false},{"id":565664,"name":"Wenjian Cao","orcid":"0009-0009-3911-7496","position":3,"is_corresponding":false},{"id":413135,"name":"Jiayi Luo","orcid":"0000-0002-9873-0671","position":4,"is_corresponding":false},{"id":18350,"name":"Yuanxin Xi","orcid":"0000-0001-5509-2043","position":5,"is_corresponding":false},{"id":311135,"name":"Xiaochao Tan","orcid":"0000-0002-8603-5700","position":6,"is_corresponding":false},{"id":552685,"name":"Kuanwei Sheng","orcid":"0000-0002-7155-9915","position":7,"is_corresponding":false},{"id":694112,"name":"Young‐Ho Ahn","orcid":"0000-0002-1084-0367","position":8,"is_corresponding":false},{"id":694113,"name":"Sieun Lee","orcid":"0000-0002-9959-6005","position":9,"is_corresponding":false},{"id":228169,"name":"Edwin R. 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