{"doi":"10.1016/j.celrep.2021.108984","title":"Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies","abstract":"Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization are not well understood. Here, we present cryoelectron microscopy (cryo-EM) structures of diverse glycan cap antibodies that variably synergize with GP base-binding antibodies. These structures describe a conserved site of vulnerability that anchors the mucin-like domains (MLDs) to the glycan cap, which we call the MLD anchor and cradle. Antibodies that bind to the MLD cradle share common features, including use of IGHV1-69 and IGHJ6 germline genes, which exploit hydrophobic residues and form β-hairpin structures to mimic the MLD anchor, disrupt MLD attachment, destabilize GP quaternary structure, and block cleavage events required for receptor binding. Our results provide a molecular basis for ebolavirus neutralization by broadly reactive glycan cap antibodies.","journal":"Cell Reports","year":2021,"id":166689,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106497,"name":"Pavlo Gilchuk","orcid":"0000-0002-3212-007X","position":1,"is_corresponding":false},{"id":286771,"name":"Philipp A. Ilinykh","orcid":null,"position":2,"is_corresponding":false},{"id":283932,"name":"Kai Huang","orcid":"0000-0002-3373-5594","position":3,"is_corresponding":false},{"id":283933,"name":"Natalia A. Kuzmina","orcid":"0000-0001-6650-9369","position":4,"is_corresponding":false},{"id":568397,"name":"Xiaoli Shen","orcid":"0000-0001-6352-5654","position":5,"is_corresponding":false},{"id":253669,"name":"Jessica F. Bruhn","orcid":"0000-0002-3356-5994","position":6,"is_corresponding":false},{"id":286772,"name":"Aubrey L. Bryan","orcid":null,"position":7,"is_corresponding":false},{"id":283937,"name":"Edgar Davidson","orcid":"0000-0002-3333-2314","position":8,"is_corresponding":false},{"id":283938,"name":"Benjamin J. Doranz","orcid":"0000-0002-8245-3083","position":9,"is_corresponding":false},{"id":106507,"name":"Lauren E. Williamson","orcid":null,"position":10,"is_corresponding":false},{"id":249506,"name":"Jeffrey Copps","orcid":"0000-0003-4793-7258","position":11,"is_corresponding":false},{"id":283939,"name":"Tanwee Alkutkar","orcid":"0000-0002-7530-7424","position":12,"is_corresponding":false},{"id":485161,"name":"Andrew I. Flyak","orcid":"0000-0002-8722-479X","position":13,"is_corresponding":false},{"id":235604,"name":"Alexander Bukreyev","orcid":"0000-0002-0342-4824","position":14,"is_corresponding":false},{"id":106531,"name":"James E. Crowe","orcid":"0000-0002-0049-1079","position":15,"is_corresponding":false},{"id":230082,"name":"Andrew B. Ward","orcid":"0000-0001-7153-3769","position":16,"is_corresponding":false},{"id":283929,"name":"Charles D. Murin","orcid":"0000-0002-1610-9276","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-18T23:45:49.644768Z","pmid":"33852862","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}