{"doi":"10.1016/j.celrep.2021.108830","title":"Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis","abstract":"mice are viable but become hyperglycemic and glucose intolerant due to impaired insulin transcription and β-cell proliferation and maintenance. Mechanistically, Rab1A mediates AA-mTORC1 signaling, particularly branched chain amino acids (BCAA), to regulate the stability and localization of the insulin transcription factor Pdx1. Collectively, these results reveal a physiological role of aa-Rab1A-mTORC1 signaling in the control of whole-body glucose homeostasis in mammals. Intriguingly, Rab1A expression is reduced in β-cells of type 2 diabetes (T2D) patients, which is correlated with loss of insulin expression, suggesting that Rab1A downregulation contributes to T2D progression.","journal":"Cell Reports","year":2021,"id":159962,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":253741,"name":"Xiaowen Wang","orcid":"0000-0003-3922-0126","position":1,"is_corresponding":false},{"id":672043,"name":"Ziqiang Yuan","orcid":"0000-0003-3957-1567","position":2,"is_corresponding":false},{"id":548438,"name":"Sarah J. Radford","orcid":"0000-0002-7052-7153","position":3,"is_corresponding":false},{"id":244937,"name":"Chen Liu","orcid":"0009-0003-0430-6146","position":4,"is_corresponding":false},{"id":381008,"name":"Steven K. Libutti","orcid":"0000-0003-2313-9809","position":5,"is_corresponding":false},{"id":640565,"name":"X.F. Steven Zheng","orcid":"0000-0003-0813-3599","position":6,"is_corresponding":false},{"id":672042,"name":"Xin Zhang","orcid":"0000-0002-2519-4441","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-18T23:44:43.908634Z","pmid":"33730578","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}