{"doi":"10.1016/j.celrep.2021.108716","title":"The E protein-TCF1 axis controls γδ T cell development and effector fate","abstract":"TCF1 plays a critical role in T lineage commitment and the development of αβ lineage T cells, but its role in γδ T cell development remains poorly understood. Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls TCF1 expression through an E-protein-bound regulatory element in the Tcf7 locus, and this axis regulates both γδ T lineage commitment and effector fate. Indeed, the level of TCF1 expression plays an important role in setting the threshold for γδ T lineage commitment and modulates the ability of TCR signaling to influence effector fate adoption by γδ T lineage progenitors. This finding provides mechanistic insight into how TCR-mediated repression of E proteins promotes the development of γδ T cells and their adoption of the interleukin (IL)-17-producing effector fate. IL-17-producing γδ T cells have been implicated in cancer progression and in the pathogenesis of psoriasis and multiple sclerosis.","journal":"Cell Reports","year":2021,"id":165616,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":441296,"name":"Alejandra Contreras","orcid":"0000-0003-3653-5958","position":1,"is_corresponding":false},{"id":264586,"name":"Anjali Verma","orcid":"0000-0003-4031-5966","position":2,"is_corresponding":false},{"id":397071,"name":"Xiang Qiu","orcid":"0000-0001-9161-9033","position":3,"is_corresponding":false},{"id":471416,"name":"Christelle Harly","orcid":"0000-0002-8045-9166","position":4,"is_corresponding":false},{"id":689387,"name":"Freddy Radtke","orcid":"0000-0003-4315-4045","position":5,"is_corresponding":false},{"id":378627,"name":"Juan Carlos Zúñiga‐Pflücker","orcid":"0000-0003-2538-3178","position":6,"is_corresponding":false},{"id":236081,"name":"Cornelis Murre","orcid":"0000-0003-2437-507X","position":7,"is_corresponding":false},{"id":271042,"name":"Hai‐Hui Xue","orcid":"0000-0002-9163-7669","position":8,"is_corresponding":false},{"id":264588,"name":"Jyoti Misra Sen","orcid":"0000-0002-6365-0866","position":9,"is_corresponding":false},{"id":441297,"name":"David L. Wiest","orcid":"0000-0002-0792-3188","position":10,"is_corresponding":false},{"id":689386,"name":"Shawn P. Fahl","orcid":"0000-0002-0489-2048","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:45:40.838485Z","pmid":"33535043","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}