{"doi":"10.1016/j.celrep.2020.108656","title":"FOS licenses early events in stem cell activation driving skeletal muscle regeneration","abstract":"Muscle satellite cells (SCs) are a quiescent (non-proliferative) stem cell population in uninjured skeletal muscle. Although SCs have been investigated for nearly 60 years, the molecular drivers that transform quiescent SCs into the rapidly dividing (activated) stem/progenitor cells that mediate muscle repair after injury remain largely unknown. Here we identify a prominent FBJ osteosarcoma oncogene (Fos) mRNA and protein signature in recently activated SCs that is rapidly, heterogeneously, and transiently induced by muscle damage. We further reveal a requirement for FOS to efficiently initiate key stem cell functions, including cell cycle entry, proliferative expansion, and muscle regeneration, via induction of \"pro-regenerative\" target genes that stimulate cell migration, division, and differentiation. Disruption of one of these Fos/AP-1 targets, NAD(+)-consuming mono-ADP-ribosyl-transferase 1 (Art1), in SCs delays cell cycle entry and impedes progenitor cell expansion and muscle regeneration. This work uncovers an early-activated FOS/ART1/mono-ADP-ribosylation (MARylation) pathway that is essential for stem cell-regenerative responses.","journal":"Cell Reports","year":2021,"id":149331,"datarank":0.7037021823343717,"base_score":4.6913478822291435,"endowment":4.6913478822291435,"self_citation_contribution":0.7037021823343717,"citation_network_contribution":0.0,"self_endowment_contribution":0.7037021823343717,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":108,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":635009,"name":"Naftali Horwitz","orcid":"0000-0003-2714-7152","position":1,"is_corresponding":false},{"id":635010,"name":"Feodor D. Price","orcid":"0000-0001-6773-5675","position":2,"is_corresponding":false},{"id":635011,"name":"Alfredo González","orcid":"0000-0001-8963-3135","position":3,"is_corresponding":false},{"id":635012,"name":"Michelle Ko","orcid":"0000-0002-5557-2749","position":4,"is_corresponding":false},{"id":235450,"name":"Özge Vargel Bölükbaşı","orcid":"0000-0003-4013-6343","position":5,"is_corresponding":false},{"id":635813,"name":"Kathleen A. Messemer","orcid":null,"position":6,"is_corresponding":false},{"id":635013,"name":"Sonia Chen","orcid":"0000-0002-1124-1040","position":7,"is_corresponding":false},{"id":92222,"name":"Manisha Sinha","orcid":"0000-0002-2344-7978","position":8,"is_corresponding":false},{"id":68239,"name":"Lee L. Rubin","orcid":"0000-0002-8658-841X","position":9,"is_corresponding":false},{"id":59412,"name":"Amy J. Wagers","orcid":"0000-0002-0066-0485","position":10,"is_corresponding":false},{"id":635812,"name":"Albert E. Almada","orcid":null,"position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:42:51.282401Z","pmid":"33503437","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}