{"doi":"10.1016/j.celrep.2020.108571","title":"Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer","abstract":"Here, we report that functional heterogeneity of macrophages in cancer could be determined by the nature of their precursors: monocytes (Mons) and monocytic myeloid-derived suppressor cells (M-MDSCs). Macrophages that are differentiated from M-MDSCs, but not from Mons, are immune suppressive, with a genomic profile matching that of M-MDSCs. Immune-suppressive activity of M-MDSC-derived macrophages is dependent on the persistent expression of S100A9 protein in these cells. S100A9 also promotes M2 polarization of macrophages. Tissue-resident- and Mon-derived macrophages lack expression of this protein. S100A9-dependent immune-suppressive activity of macrophages involves transcription factor C/EBPβ. The presence of S100A9-positive macrophages in tumor tissues is associated with shorter survival in patients with head and neck cancer and poor response to PD-1 antibody treatment in patients with metastatic melanoma. Thus, this study reveals the pathway of the development of immune-suppressive macrophages and suggests an approach to their selective targeting.","journal":"Cell Reports","year":2020,"id":50823,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":178,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9434,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251281,"name":"Fang Wang","orcid":"0009-0008-5160-7909","position":1,"is_corresponding":false},{"id":251282,"name":"Hui Deng","orcid":"0000-0002-9937-1391","position":2,"is_corresponding":false},{"id":251283,"name":"Thomas Condamine","orcid":"0000-0001-9450-2762","position":3,"is_corresponding":false},{"id":253111,"name":"Vinit Kumar","orcid":null,"position":4,"is_corresponding":false},{"id":245073,"name":"Michela Perego","orcid":"0000-0002-5671-928X","position":5,"is_corresponding":false},{"id":245076,"name":"Andrew V. Kossenkov","orcid":"0000-0002-1536-0418","position":6,"is_corresponding":false},{"id":251284,"name":"Luis J. Montaner","orcid":"0000-0001-5799-6759","position":7,"is_corresponding":false},{"id":251285,"name":"Xiaowei Xu","orcid":"0000-0003-4098-7690","position":8,"is_corresponding":false},{"id":42121,"name":"Wei Xu","orcid":"0009-0005-8331-7939","position":9,"is_corresponding":false},{"id":251286,"name":"Cathy Zheng","orcid":"0000-0002-0092-5463","position":10,"is_corresponding":false},{"id":253112,"name":"Lynn M. Schuchter","orcid":null,"position":11,"is_corresponding":false},{"id":3837,"name":"Ravi K. Amaravadi","orcid":"0000-0002-5768-2474","position":12,"is_corresponding":false},{"id":251287,"name":"Tara C. Mitchell","orcid":"0000-0002-8186-7284","position":13,"is_corresponding":false},{"id":251288,"name":"Giorgos C. Karakousis","orcid":"0000-0002-9321-2795","position":14,"is_corresponding":false},{"id":251289,"name":"Charles Mulligan","orcid":"0000-0001-8021-2967","position":15,"is_corresponding":false},{"id":253113,"name":"Brian Nam","orcid":null,"position":16,"is_corresponding":false},{"id":251290,"name":"Gregory A. Masters","orcid":"0000-0002-8538-3826","position":17,"is_corresponding":false},{"id":253114,"name":"Neil Hockstein","orcid":null,"position":18,"is_corresponding":false},{"id":251291,"name":"Joseph Bennett","orcid":"0000-0003-0030-797X","position":19,"is_corresponding":false},{"id":245075,"name":"Yulia Nefedova","orcid":"0000-0002-5121-9294","position":20,"is_corresponding":false},{"id":110069,"name":"Dmitry I. Gabrilovich","orcid":"0000-0001-9913-6407","position":21,"is_corresponding":false},{"id":251280,"name":"Taekyoung Kwak","orcid":"0009-0007-3622-8305","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-18T20:39:29.006085Z","pmid":"33378668","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}