{"doi":"10.1016/j.celrep.2020.108553","title":"Airway-Associated Macrophages in Homeostasis and Repair","abstract":"There is an increasing appreciation for the heterogeneity of myeloid lineages in the lung, but relatively little is known about populations specifically associated with the conducting airways. We use single-cell RNA sequencing, flow cytometry, and immunofluorescence to characterize myeloid cells of the mouse trachea during homeostasis and epithelial injury/repair. We identify submucosal macrophages, similar to lung interstitial macrophages, and intraepithelial macrophages. Following injury, there are early increases in neutrophils and submucosal macrophages, including M2-like macrophages. Intraepithelial macrophages are lost after injury and later restored by CCR2+ monocytes. We show that repair of the tracheal epithelium is impaired in Ccr2-deficient mice. Mast cells and group 2 innate lymphoid cells are sources of interleukin-13 (IL-13) that polarize macrophages and directly influence basal cell behaviors. Their proximity to the airway epithelium establishes these myeloid populations as potential therapeutic targets for airway disease.","journal":"Cell Reports","year":2020,"id":62018,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":228729,"name":"Alexandra B. Ysasi","orcid":"0000-0002-2932-870X","position":1,"is_corresponding":false},{"id":110437,"name":"Riley M.F. Pihl","orcid":"0000-0002-6160-5324","position":2,"is_corresponding":false},{"id":89670,"name":"Carlos Villacorta-Martín","orcid":"0000-0002-1350-465X","position":3,"is_corresponding":false},{"id":328223,"name":"Hailey M. Heston","orcid":"0000-0002-9308-1908","position":4,"is_corresponding":false},{"id":328224,"name":"Hanne M.K. Richardson","orcid":"0000-0002-3442-136X","position":5,"is_corresponding":false},{"id":328225,"name":"Bibek R. Thapa","orcid":"0000-0001-5254-0808","position":6,"is_corresponding":false},{"id":328226,"name":"Noah R. Moniz","orcid":"0000-0002-1706-7557","position":7,"is_corresponding":false},{"id":110438,"name":"Anna C. Belkina","orcid":"0000-0001-7967-6254","position":8,"is_corresponding":false},{"id":92271,"name":"Sarah A. Mazzilli","orcid":"0000-0002-9187-2722","position":9,"is_corresponding":false},{"id":18143,"name":"Jason R. Rock","orcid":"0000-0001-5467-3364","position":10,"is_corresponding":false},{"id":228727,"name":"Anna Engler","orcid":"0000-0002-2992-5512","position":0,"is_corresponding":true}],"reference_count":27,"raw_metadata":null,"created_at":"2026-07-18T21:10:11.612909Z","pmid":"33378665","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}